Calcium channel ‘agonist’ BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes
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Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca<sup>2+</sup> Channel
2019, CellCitation Excerpt :The relatively poor resolution of this specific region, compared to the overall high resolution of the pore domain of rCav1.1-B, may suggest a metastable state of these segments in the present structure (Figure S4E). It has been rigorously characterized that DHP agonists occupy the same binding site as antagonists (Greenberg et al., 1984; Hockerman et al., 1997c; Janis et al., 1984; Peterson et al., 1996; Sanguinetti and Kass, 1984) (Table S1). Consistently, nifedipine and Bay K 8644 can be well overlaid with the dihydropyridine ring completely overlapped, and the phenyl ring aligned on the same plane with slight rotation (Figure 3B).
BAY-K 8644
2009, xPharm: The Comprehensive Pharmacology ReferenceDifferential sensitivity of calcium channels to dihydropyridines. The modulated receptor hypothesis
1986, Biochemical Pharmacology
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