Potassium currents recorded in type I carotid body cells from the neonatal rat and their modulation by chemoexcitatory agents
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Respiratory stimulant drugs in the post-operative setting
2013, Respiratory Physiology and NeurobiologyCitation Excerpt :Given that therapeutic plasma concentration of doxapram is in the order of 4–5 μM (see below), these studies suggest that doxapram may increase ventilatory drive via inhibition of TASK channels and to a lesser extent the BK channel. The effects of almitrine on ionic currents from isolated rat type 1 glomus cells have been reported (Lopez-Lopez et al., 1998; Peers and O’Donnell, 1990). Almitrine inhibits BK currents (IC50 ∼ 200 nM) without altering voltage dependent K+, Na+, or calcium currents.
Characterization of an ATP-sensitive K<sup>+</sup> channel in rat carotid body glomus cells
2011, Respiratory Physiology and NeurobiologyCitation Excerpt :This suggests that ATP levels are maintained at millimolar levels during even prolonged hypoxic stress, and millimolar levels of ATP prevent KATP activation. This likely explains why previous investigators failed to detect the KATP channel in earlier studies (Peers and O’Donnell, 1990). If so, then a modulatory role for the KATP channel might only be manifest under conditions where ATP production is significantly impaired such as during prolonged glucose deprivation, but this may take considerable time depending on the metabolic reserves of the CB cells.
Role of MaxiK-type calcium dependent K<sup>+</sup> channels in rat carotid body hypoxia transduction during postnatal development
2011, Respiratory Physiology and NeurobiologyCitation Excerpt :It is proposed to play a role in establishing resting membrane potential, but appears to be only present in the rabbit and therefore is not an hypoxia sensor across species. The second, described in 1990, is a specific isoform of the “BK-like” K+ channel (MaxiK) which is activated by increases in intracellular calcium and cell depolarization and is inhibited by hypoxia (Peers, 1990; Peers and O’Donnell, 1990; Ross et al., 2011). This current is poorly expressed in the immediate newborn period and expression increases over the period of organ maturation, suggesting causality between the two (Hatton et al., 1997).
Oxygen sensitive Kv channels in the carotid body
2007, Respiratory Physiology and NeurobiologyTASK-like potassium channels and oxygen sensing in the carotid body
2007, Respiratory Physiology and NeurobiologyPostnatal development of carotid body glomus cell response to hypoxia
2006, Respiratory Physiology and Neurobiology