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Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain
2023, Molecular and Cellular ProteomicsPKC-epsilon activation is required for recognition memory in the rat
2013, Behavioural Brain ResearchCitation Excerpt :In humans, PKCɛ activity and expression levels are lower in the cerebral cortex of Alzheimer's disease (AD) patients [33], a phenotype that may be reduced by activation of PKCɛ in transgenic mouse models of AD [34]. Moreover, PKCɛ is highly enriched in neurons of the hippocampal circuitry in the rat [35–37], while PKC activation restored PKCɛ- and α-dependent mushroom dendritic spinogenesis and synaptogenesis in aged rats, improving as well their spatial memory retention [7]. Notwithstanding these compelling results, direct evidence for the possible implication of PKCɛ in memory mechanisms is still lacking, because most PKC pharmacological activators and inhibitors previously used may not discriminate amongst individual PKC isoforms, and activate less potently other PKCs and/or non-PKC dependent signalling pathways, e.g., DCP-LA [38,39]; similarly, the effects of isoform-specific genetic ablation is blurred from partial overlaps in the isoform function (e.g. Ref. [40]).
Maternal dietary loads of α-tocopherol differentially influence fear conditioning and spatial learning in adult offspring
2011, Physiology and BehaviorCitation Excerpt :Isoform-specific role for PKC has been demonstrated in brain development and plasticity, particularly in fine refining of neuronal network. PKCε, whose expression is particularly high in the hippocampus [27], is precociously expressed in developing brain, where it promotes neural precursor proliferation [28] and neurite outgrowth [29]. PKCα expression is low at early stages of nervous system development and it increases at more advanced stages, and it is possibly involved in synaptogenesis and apoptosis [28].
ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε
2011, Molecular and Cellular Neuroscience