Guanosine phosphate analogs modulate ethanol potentiation of GABAA-mediated synaptic currents in hippocampal CA1 neurons
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2018, NeuroToxicologyCitation Excerpt :In general, long-term potentiation (LTP) of excitatory synaptic transmission seems to require activation of glutamate receptors and inhibition of Gamma-AminoButyric Acid A (GABAA) receptors. The ethanol might inhibit LTP because short-term ethanol exposure inhibits glutamate receptor function (Lovinger et al., 1990; Bliss and Collingridge, 1993) and stimulates GABAA receptor function in the hippocampus (Weiner et al., 1994). Whereas the regulation of adenosine levels is essential for the proper function of major neurotransmitter systems in the brain, particularly glutamate (Ruby et al., 2010), the investigation of the relation of adenosine and memory after early ethanol exposure becomes relevant.
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2017, NeuropharmacologyCitation Excerpt :One of the earlier patch clamp studies performed in cultured mouse hippocampal neurons determined that concentrations of 40 mM ethanol potentiated GABA-gated current, and that increasing concentrations up to 80 mM were ineffective in producing further potentiation (Aguayo, 1990). Other early work utilizing whole–cell patch clamp recordings in rat hippocampal CA1 neurons showed that 10–50 mM concentrations of ethanol enhanced GABA-A receptor mediated fast IPSCs, and that the concentration-dependence of IPSC enhancement constituted a bell-shaped curve, with significant potentiation at 10 mM, peaking at 20 mM (Weiner et al., 1994). However, it must be stated that there have been many negative findings over the years in studies that have attempted to repeat these observations.
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This work was supported by research grants to P.L.C. from the Medical Research Council (MRC) of Canada and the Alcoholic Beverages Medical Research Foundation.
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We thank Mr. Frank Vidic for his excellent assistance with electronics and computerized data-processing and Taufik Ali Valiante for producing the TCRUNCH software for data analysis. We also thank Patricia L. Watson for helpful discussion.
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L.Z. is supported by the Bloorview Epilepsy Research Program.