Short communicationThe D-1 dopamine receptor antagonist SCH 23390 also interacts potently with brain serotonin (5-HT2) receptors☆
References (10)
Hyperactivity induced by stimulation of separate dopamine D-1 and D-2 receptors in rats with bilateral 6-OHDA lesions
Life Sci.
(1985)- et al.
In vivo (3H)spiperone binding to the rat hippocampal formation: involvement of dopamine receptors
European J. Pharmacol.
(1980) - et al.
5-HT receptor antagonist properties of SCH 23390 in vascular smooth muscle and brain
European J. Pharmacol.
(1984) Mesohippocampal dopamine system: characterization, functional and clinical implications
- et al.
Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics
Life Sci.
(1982)
There are more references available in the full text version of this article.
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Part of this work was presented at the 6th General Meeting of the European Society of Neurochemistry, Prague, Sept. 1–6, 1986.
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To whom all correspondence should be addressed.
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J.M.S. was at CIBA-GEIGY as student.
Copyright © 1986 Published by Elsevier B.V.