Analysis of the antagonistic actions of HOE 140 and other novel bradykinin analogues on the guinea-pig ileum
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Cited by (29)
Antagonistic effects of novel non-peptide chlorobenzhydryl piperazine compounds on contractile response to bradykinin in the guinea-pig ileum
2005, European Journal of PharmacologyStudy of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro
2003, European Journal of PharmacologyPeptide and non-peptide bradykinin B<inf>2</inf> receptor agonists and antagonists: A reappraisal of their pharmacology in the guinea-pig ileum
2000, European Journal of PharmacologyHoe 140 and pseudo-irreversible antagonism in the rat vas deferens in vitro
2000, European Journal of PharmacologyCitation Excerpt :Although the profile of antagonism displayed by Hoe 140 is highly dependent upon the species and tissue used for assay, most studies have shown that it is predominantly an insurmountable antagonist. Thus, Hoe 140 is an insurmountable antagonist against responses to bradykinin in guinea pig ileum (Griesbacher and Lembeck, 1992), rabbit jugular vein (Rhaleb et al., 1992; Félétou et al., 1994; Marceau et al., 1994), and guinea pig trachea (Field et al., 1992; Trifilieff et al., 1993). By contrast, Hoe 140 causes surmountable antagonism in the human umbilical vein (Marceau et al., 1994).
Ala scan analogues of HOE 140. Synthesis and biological activities
2000, European Journal of Medicinal Chemistry
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