Plasmodium falciparum: Induction, selection, and characterization of pyrimethamine-resistant mutants
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Keywords
Plasmodium falciparum
Protozoa, parasitic
Malaria, human
Pyrimethamine, antimalarial
Drug resistance
mutagenesis
Mutants
Drug effect
Bifunctional enzyme protein
Abbreviations
N-methyl-N′-nitro-N-nitro-soguanidine
(MMNG)
Dihydrofolate reductase
DHFR
Thymidylate synthetase
TS
5-fluoro-2-deoxy[6-3H]Uridine-5′-monophosphate
([6-3H]FdUMP)
l-5,10-Methylene-tetrahydrofolate
(CH2FAH4)
[5-3H]deoxyuridine-5′-phosphate
([5-3H]dUMP)
[3H]methotrexate
(3HMTX)
Erythrocytes, red blood cells
RBC
Ethylenediaminetetraacetic acid
EDTA
(N-Tris[hydroxymethyl] methyl-2-aminomethane sulfonic acid)
TES
N-2-hydroxyethylpiperazine-N′-ethanesulfonic acid
Hepes
Phosphate buffered saline
PBS
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Present address: Department of Biosciences, H.P. University, Shimla, H.P., India.
Copyright © 1986 Published by Elsevier Inc.