Colonic motility and transit in health and ulcerative colitis
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2022, GastroenterologyCitation Excerpt :They describe an increased propulsive activity, possibly due to limited absorption of water and salt along with intraluminal load from mucosal inflammation, leading to distention of the bowel wall and subsequent increased colonic propulsion.51 Relatedly, a common finding among other studies is decreased contractility, followed by rapid transit time primarily from the splenic flexure and through the rectosigmoid region.51,52 Older studies that show such decreased to absent motor activity explain these findings as a cause of paradoxical motility, in which there is accelerated intestinal transit time because of a loss of colonic haustration and decreased resistance to the flow of contents.49,53
The results of this study were presented in part at the American Gastroenterological Association meeting in Washington, D.C., in May 1989.
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Supported in part by the Inflammatory Bowel Disease Center and in part by UCLA—Harbor Collegium Research Award to S. Narasimha Reddy.