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Folic acid

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  • Cited by (32)

    • Platinum folate nanoparticles toxicity: Cancer vs. normal cells

      2013, Toxicology in Vitro
      Citation Excerpt :

      Hence, the major penetration pathway of the Pt/folate NPs to the cell is the receptor mediated endocytosis. It is well known that folic acid is required for essential cell function, namely it is necessary for the synthesis of purines and pyrimidines (Davis and Nicol, 1988) it is also known that folate receptor is overexpressed in ovarian, lung, brain, head, neck, breast cancers and has a very high affinity to the folic acid and all sorts of folic acid conjugates (Elnakat and Ratnam, 2004; Shmeeda et al., 2006). Therefore any cargo linked to the folic acid will be retained within an endocytic vesicle or released into the cytoplasm.

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