Elsevier

Life Sciences

Volume 30, Issue 9, 1 March 1982, Pages 731-738
Life Sciences

Plasma cocaine concentrations during cocaine paste smoking

https://doi.org/10.1016/0024-3205(82)90606-3Get rights and content

Abstract

Cigarettes containing cocaine paste were administered to experienced volunteer smokers in Peru, and plasma concentrations of cocaine were measured. Cocaine concentrations as high as 462 ng/ml were obtained after only three minutes of smoking cocaine paste. Subjects titrated their rate of consumption so as to achieve remarkably constant plasma concentrations during the smoking period. Areas under curve (AUC), adjusted for dose, were approximately 70% that obtained with oral or intranasal administration of cocaine to different subjects in previous experiments.

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Cited by (0)

1

Present Address: University of Oregon Hospital, Portland, OR 97200.

2

Present Address: Veterans Administration Hospital, San Francisco, CA 94121.

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