Elsevier

Tetrahedron Letters

Volume 36, Issue 8, 20 February 1995, Pages 1189-1192
Tetrahedron Letters

Absolute configuration of curacin A, a novel antimitotic agent from the tropical marine cyanobacterium Lyngbya majuscula

https://doi.org/10.1016/0040-4039(95)00030-GGet rights and content

Abstract

Curacin A is a structurally novel antimitotic agent isolated from the Caribbean cyanobacterium Lyngbya majuscula. Its planar structure has been previously determined from a spectroscopic investigation. Here, we define the complete relative and absolute configuration of curacin A by comparison of products obtained from chemical degradation of the natural product with the same substances prepared by synthesis. Curacin A is shown to have 2R, 13R, 19R, 21S absolute configuration.

Curacin A is shown to have 2R,13R,19R,21S configuration by a combination of degradative and synthetic studies.

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