Absolute configuration of curacin A, a novel antimitotic agent from the tropical marine cyanobacterium Lyngbya majuscula
Curacin A is shown to have 2R,13R,19R,21S configuration by a combination of degradative and synthetic studies.
References (17)
Pharmacol. Ther.
(1992)- et al.
- et al.
J. Org. Chem.
(1994) - Hamel, E.; Blokhin, A.V.; Nagle, D.G.; Yoo, H.-D.; Gerwick, W.H. Drug Dev. Res. (in...
- Sackett, D.L. Pharmacol. Ther., in...
- et al.
J. Org. Chem.
(1991)
Cited by (66)
Biogenetic Diversity of Cyanobacterial Metabolites
2007, Advances in Applied MicrobiologyCitation Excerpt :By far, SAM‐mediated methylation of methyl carbons of polyketide intermediates is the most common. The curacins from Lyngbya (Fig. 32B) are a family of thiazoline‐containing compounds resulting from mixed PKS/NRPS biosynthesis (Gerwick et al., 1994; Márquez et al., 1998; Nagle et al., 1995; Yoo and Gerwick, 1995). The curacins differ from one another based on double bond geometry or methyl branching of the side chain.
Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10
2002, Biochemical PharmacologyCitation Excerpt :Spongistatin 1, halichondrin B, halistatin 1 and 2, homohalichondrin D, and hemiasterlin were isolated from a variety of sponges [6–13]. Curacin A was isolated from a blue-green algae [14]. Dolastatin 10 and the depsipeptide dolastatin 15 are peptides discovered from the sea mollusk Dolabella auricularia[15–18].
Marine sulfur-containing natural products
2001, Studies in Natural Products ChemistryNitrogen-containing metabolites from marine cyanobacteria
2001, Alkaloids: Chemistry and Biology