Effects of modulation of hepatic glutathione on biotransformation and covalent binding of aflatoxin B1 to DNA in the mouse
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Aflatoxin detoxification in tortillas using an infrared radiation thermo-alkaline process: Cytotoxic and genotoxic evaluation
2020, Food ControlCitation Excerpt :The production of GSH by HepG2 cells is conditioned by the detoxification mechanisms present in them, causing a higher concentration of GSH, the higher the production of AFB1-DNA adducts. This fact is of great importance since it depends on the susceptibility of an organism to produce hepatocarcinogenicity (Monroe & Eaton, 1988). In this investigation, AFB1 and ME achieved greater production of GSH compared with the processes of nixtamalization, which could mean that the cellular detoxification mechanism began with these samples, but with tortilla extracts of both nixtamalization methods it was unnecessary because its toxicity decreased until it was comparable with the negative control.
Aflatoxins
2018, Encyclopedia of CancerHeterologous expression and functional characterization of avian mu-class glutathione S-transferases
2013, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyCitation Excerpt :At pharmacologically relevant concentrations of AFB1, the P450 1A5 isoform is responsible for > 98% of AFB1 bioactivation in the liver, whereas P450 3A37 predominates at much higher substrate concentrations, unlikely to occur in vivo (Rawal and Coulombe, 2011). Numerous studies indicate that AFB1 resistance and susceptibility is strongly associated with GST-mediated detoxification of AFBO (Monroe and Eaton, 1988; Ramsdell and Eaton, 1990). Mice are resistant to the acute and chronic toxic effects of AFB1 due to constitutive expression of the alpha-class A3 subunit (mGSTA3, previously designated Yc and Ya3) that has high affinity toward AFBO (Buetler et al., 1992; Hayes et al., 1992).
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