Cell
Volume 46, Issue 3, 1 August 1986, Pages 437-445
ArticleBiosynthesis and processing of the α subunit of the voltage-sensitive sodium channel in rat brain neurons
References (41)
Voltage-sensitive sodium ion channels
Molecular properties and functional reconstitution
Trends Biochem. Sci.
(1984)- et al.
Appearance of [3H]saxitoxin binding sites in developing rat brain
Dev. Brain Res.
(1983) Sodium channels in electrically excitable cells
Cell
(1982)- et al.
Cyclic AMP-dependent phosphorylation of the α subunit of the sodium channel in synaptic nerve ending particles
J. Biol. Chem.
(1984) - et al.
Selective phosphorylation of the α subunit of the sodium channel by cAMP-dependent protein kinase
J. Biol. Chem.
(1982) - et al.
Biosynthesis of the N- and O-linked oligosaccharides of the low density lipoprotein receptor
J. Biol. Chem.
(1983) - et al.
Compartmental organization of the Golgi stack
Cell
(1985) - et al.
Attachment of terminal N-acetylglucosamine to asparagine-linked oligosaccharides occurs in central cisternae of the Golgi stack
Cell
(1985) - et al.
The lectins: carbohydrate-binding proteins of plants and animals
Adv. Carbohydr. Chem. Biochem.
(1978) - et al.
The sodium channel from rat brain: purification and subunit composition
J. Biol. Chem.
(1984)
The saxitoxin receptor of the sodium channel from rat brain: evidence for two nonidentical subunits
J. Biol. Chem.
(1982)
Biosynthesis and glycosylation of the insulin receptor
Evidence for a single polypeptide precursor of the two major subunits
J. Biol. Chem.
(1983)
Purification and functional reconstitution of the voltage-sensitive sodium channel from rabbit T-tubular membranes
J. Biol. Chem.
(1985)
Ontogenic appearance of Na+ channels characterized as high affinity binding sites for tetrodotoxin during development of the rat nervous and skeletal muscle systems
Biochem. Biophys. Res. Comm.
(1983)
Inhibition of glycosylation with tunicamycin blocks assembly of newly synthesized acetylcholine receptor subunits in muscle cells
J. Biol. Chem.
(1982)
The sodium channel from rat brain
Separation and characterization of subunits
J. Biol. Chem.
(1985)
The sodium channel from rat brain
Role of the β1 and β2 subunits in saxitoxin binding
J. Biol. Chem.
(1986)
Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples
J. Biol. Chem.
(1981)
Role of glycosylation in the processing of newly translated insulin proreceptor in 3T3-L1 adipocytes
J. Biol. Chem.
(1984)
The (Na+ + K+)-ATPase of chick sensory neurons
Studies on biosynthesis and intracellular transport
J. Biol. Chem.
(1986)
Cited by (175)
Spinal cord injury-mediated changes in electrophysiological properties of rat gastric nodose ganglion neurons
2022, Experimental NeurologyFunctional analysis of three Na<inf>v</inf>1.6 mutations causing early infantile epileptic encephalopathy
2020, Biochimica et Biophysica Acta - Molecular Basis of DiseaseN-Glycosylation of the voltage-gated sodium channel β2 subunit is required for efficient trafficking of Na<inf>V</inf>1.5/β2 to the plasma membrane
2019, Journal of Biological ChemistryCitation Excerpt :The implication of β subunits in promoting trafficking of the α subunit to the plasma membrane is a common finding seen in the literature (5, 30, 31). For β2 in particular, it has long been believed that covalent assembly of α/β2 takes place right before their arrival to the plasma membrane (13) or at least after the subunits have left the Golgi apparatus (14). This is consistent with data from Scn2b deletion in mice, which causes, both in ventricular myocytes (25) and in primary hippocampal neuron cultures (26), an approximately 40% reduction of α subunits at the cell surface.
Copyright © 1986