Cell
ArticleMembers of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system
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The role of acetylcholine and its receptors in retinal processing
2016, The Curated Reference Collection in Neuroscience and Biobehavioral PsychologyDiscovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: Pharmacophore modeling and structure-activity relationship studies
2013, Bioorganic and Medicinal ChemistryCitation Excerpt :These subunits assemble to form multiple subtypes that are characterized by distinct biochemical properties (e.g., ion selectivity, conductance, mean channel open time, permeability to Ca2+, and desensitization rate).4–6 Importantly, each subunit is expressed in unique spatial and developmental patterns, suggesting the possibility that individual subtypes may play distinct roles in certain physiological processes.6,7 Knowledge of these roles will pave the way toward the identification of novel therapeutic targets and allow the development of more targeted pharmacotherapy with reduced side effects.
A review of experimental techniques used for the heterologous expression of nicotinic acetylcholine receptors
2009, Biochemical PharmacologyCitation Excerpt :Over a two-year period in the early 1980s (1982–1983), several papers were published that described the isolation of cDNAs encoding the four subunits of the Torpedo electric organ nAChR (the α[36–38], β[39], γ[40,41] and δ[39] subunits). Following the cloning of Torpedo nAChRs, nAChR subunit cDNAs have been cloned from numerous other species, including the vertebrate muscle-type nAChR subunits (α1, β1, γ, δ and ɛ) [42–47] and the vertebrate neuronal subunits (α2–α10 and β2–β4) [48–58]. In addition, nAChRs have been cloned from numerous invertebrate species [6,59–61].
Alpha 7 nicotinic acetylcholine receptors: Molecular pharmacology and role in neuroprotection
2008, Current Anaesthesia and Critical CarePostnatal expression of α2 nicotinic acetylcholine receptor subunit mRNA in developing cortex and hippocampus
2006, Journal of Chemical Neuroanatomy
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Present address: Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109.