Cell
Volume 77, Issue 1, 8 April 1994, Pages 83-93
ArticleA novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
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2020, Biochemical PharmacologyCitation Excerpt :One of these mechanisms involves the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway [125]. PI3K is a family of lipid kinases in which PI3Kγ isoform is activated by the βγ subunits of Gi protein-coupled receptors, including the opioid receptors [126]. In this context, we tested the hypothesis that the PI3Kγ/AKT signaling would be the initial step involved in the stimulation of the NO pathway by morphine and/or other opioids [92].
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