ORIGINAL ARTICLESIdentification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase
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Loss of AIRE-Mediated Immune Tolerance and the Skin
2022, Journal of Investigative DermatologyCitation Excerpt :Nevertheless, several specific AAbs have been useful in diagnostics or prognostics. For example, AAbs to P450c21 and P450c17 cytochromes predate the emergence of AD symptoms and are recommended to be monitored annually (Husebye et al., 2009; Krohn et al., 1992; Uibo et al., 1994). The cause for the development of anti-cytokine AAbs in APECED is still unknown because cytokines do not fall into the category of AIRE-induced organ-specific autoantigens.
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