Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function
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Cited by (255)
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure
2021, European Journal of Medicinal ChemistryCitation Excerpt :In general, PDEs are found in their dimeric form through the association of two enzymatic subunits [7]. The monomeric structure of all isoforms is composed by 3 distinct domains: a catalytic, an N-terminal, and a C-terminal domains [8–10]. The C-terminal domain is conserved in all PDE families, with the exception of PDE6, which shares 18–46% homology [11].
Inhibition of type 4 cAMP-phosphodiesterases (PDE4s) in mice induces hypothermia via effects on behavioral and central autonomous thermoregulation
2020, Biochemical PharmacologyCitation Excerpt :As such a significant decrease in body temperature may by itself exert critical effects on immune responses, and because the role of PDE4 in body temperature regulation remains poorly understood, we have further explored this observation. Piclamilast/RP73401 [29,30], Rolipram [31], Roflumilast [32], Cilostamide [33], Chlorcyclizine [34], Spiperone [35], and Pimozide [36] were from Cayman Chemical (Ann Arbor, MI, USA). YM976 [37] was obtained from Tocris/Bio-Techne (Minneapolis, MN, USA), Naloxone [38] from MP Biomedicals (Irvine, CA), Domperidone [39] from Alfa Aesar (Haverhill, MA, USA), Ketanserin [35] from TCI America (Portland, OR, USA), Propranolol [40,41] from Millipore Sigma (St. Louis, MO, USA), and RS25344 [42] from Santa Cruz Biotech (Santa Cruz, CA, USA).
Cyclic nucleotide phosphodiesterase inhibitors: possible therapeutic drugs for female fertility regulation
2020, European Journal of PharmacologyNegative inotropic effects of diadenosine tetraphosphate are mediated by protein kinase C and phosphodiesterases stimulation in the rat heart
2018, European Journal of PharmacologyCitation Excerpt :This assumption allows suggesting that Ap4A-induced PDE stimulation in the rat heart is PKC dependent. It is known that N-terminal domain of PDE4 contain specific phosphorylation sites for protein kinases, while PDE3 represents several sites for phosphorylation by PKC (Hunter et al., 2009; Thompson, 1991). There have been demonstrated PKC mediated phosphorylation of PDE3 and PDE4 in various tissues including heart (Bian et al., 2000; Hunter et al., 2009).
Inhibition of mitochondrial pyruvate transport by Zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina
2013, Journal of Biological ChemistryEtiological relationships of parotid saliva cyclic nucleotides in patients with taste and smell dysfunction
2012, Archives of Oral Biology