Multidrug resistance gene family and chemical carcinogens
References (62)
- et al.
Internal duplication and homology with bacterial transport proteins in the ndr1 (P-glycoprotein) gene from multidrug-resistant human cells
Cell
(1986) - et al.
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
J. biol. Chem.
(1990) - et al.
Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum
Cell
(1989) - et al.
Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins
Cell
(1986) - et al.
Regulatory gene product of the Ah complex. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methyl-chlanthrene binding to several moieties in mouse liver cytosol
J. biol. Chem.
(1981) - et al.
Differential over-expression of three mdr gene family members in multidrug-resistant J774.2 mouse cells
J. biol. Chem.
(1989) - et al.
Induction of mRNA specific for cytochrome P1450 in wild type and variant mouse hepatoma cells
J. biol. Chem.
(1983) - et al.
Control of gene expression by 2,3-7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5′-ward of the cytochrome P1-450 gene
J. biol. Chem.
(1986) - et al.
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Cell
(1986) - et al.
The Ah locus: correlation ff intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA
Cell
(1982)
The human resistance (mdr 1) gene. cDNA cloning and transcription initiation
J. biol. Chem.
(1987)
Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene
J. biol. Chem.
(1987)
Multidrug resistance
Adv. Cancer Res.
(1989)
Sequence of mdr3 cDNA encoding a human P-glycoprotein
Gene
(1988)
Induction of aryl hydrocarbon (Benzo[a]pyrene) hydroxylase in liver cell culture by temporary inhibition of protein synthesis
J. biol. Chem.
(1973)
Cytoplasmic orientation and two-domain structure of the multidrug transporter, P-glycoprotein, demonstrated with sequence-specific antibodies
J. biol. Chem.
(1989)
Differential toxicity response of normal and neoplastic cells in vitro to 3,4-benzopyrene and 3-methyl-cholanthrene
Br. J. Cancer
(1964)
Induction of different isozymes of cytochrome P-450 and of microsomal epoxide hydrolase it liver by 2-acetylaminofluorene and structurally related compounds
Eur. J. Biochem.
(1986)
Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr 1 gene abolish its ability to confer multi-drug resistance
Molec. cell. Biol.
(1989)
In vitro cell transformation with chemical carcinogens
Nature, Lond.
(1963)
In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons
J. natn. Cancer Inst.
(1965)
Coinduction of MDR-1 multidrug resistance and cytochrome P-450 genes in rat liver by xenobiotics
J. natn. Cancer Inst.
(1988)
Transformation of rat liver epithelial cells with v-H-ras of raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals
Carcinogenesis
(1988)
Pleitropic drug resistance in hepatocytes induced by carcinogens administered to rats
Cancer Res.
(1987)
Carcinogen-induced drug resistance in rat hepatocytes
Cancer Res.
(1981)
Structure and expression of the human MDR (P-glycoprotein) gene family
Molec. cell. Biol.
(1989)
Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells
Cell Growth and Differentiation
(1990)
DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein
Molec. cell. Biol.
(1982)
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Co-distribution of unoccupied receptor with cytosolic marker enzymes during fractionation of mouse liver, rat liver and cultured HePa-1c1 cells
Eur. J. Biochem.
(1986)
The effects of carcinogenic hydrocarbons on rodent primary cells in vitro
J. Cell comp. Physiol.
(1965)
The biochemistry of P-glycoprotein-mediated multidrug resistance
A. Rev. Biochem.
(1989)
Cited by (60)
Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse
2006, Journal of Pharmacological and Toxicological MethodsMultiple drug resistance, antimutagenesis and anticarcinogenesis
2005, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisAn oncological view on the blood-testis barrier
2002, Lancet OncologyCitation Excerpt :In liver, kidney, and adrenal gland, P-glycoprotein is present at the basolateral side of the capillary endothelial cells.33,34 Several agents are proposed to be transported and excreted by P-glycoprotein, including carcinogens, xenobiotics, hormones, and bilirubin.35–38 P-glycoprotein-mediated efflux of one compound can be inhibited by coadministration of other compounds, such as cyclosporin and PSC 833, a non-immunosuppressant cyclosporin analogue.
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