Original articleCodeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-α1, interferon-β1, and other 9p21 markers in human malignant cell lines
References (36)
- et al.
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia
Genomics
(1992) - et al.
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
Cell
(1992) Mammalian G1 cyclins
Cell
(1993)- et al.
Homozygous loss of the cyclin-dependent kinase 4 inhibitor (p16) gene in human leukemias
Blood
(1994) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Anal Biochem
(1976)- et al.
Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization
Genomics
(1992) - et al.
Homozygous deletion of the α- and β-interferon genes in human leukemia and derived cell lines
- et al.
Deletions of interferon genes in acute lymphoblastic leukemia
N Engl J Med
(1990) - et al.
Absence of IFNA and IFNB genes from human malignant cell lines and lack of correlation with cellular sensitivity to interferons
Cancer Res
(1990) - et al.
Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas
Cancer Res
(1992)
Localization of chromosome 9p homozygous deletions in glioma cell lines with markers constituting a continuous linkage group
Cancer Res
(1993)
Homozygous deletions within human chromosome band 9p21 in melanoma
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers
Cancer Res
(1993)
Homozygous and hemizygous deletions of 9p centromeric to the interferon genes in lung cancer
Cancer Res
(1994)
Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas
Cancer Res
(1993)
Homozygous deletions of 9p21 in primary human bladder detected by comparative multiplex polymerase chain reaction
Cancer Res
(1994)
Homozygous deletions within chromosomal bands 9p21–22 in bladder cancer
Cancer Res
(1994)
Frequent loss of chromosome 9p21–22 early in head and neck cancer progression
Cancer Res
(1994)
Cited by (76)
HPV-positive clinically advanced squamous cell carcinoma of the urinary bladder (aBSCC): A comprehensive genomic profiling (CGP) study
2023, Urologic Oncology: Seminars and Original InvestigationsNovel synthetic lethality drug target in urothelial bladder cancer based on MTAP genomic loss
2023, Urologic Oncology: Seminars and Original InvestigationsScalable Atroposelective Synthesis of MRTX1719: An Inhibitor of the PRMT5/MTA Complex
2023, Organic Process Research and DevelopmentAll is not lost: learning from 9p21 loss in cancer
2022, Trends in ImmunologyCitation Excerpt :In the study by Han et al. [2], the authors defined ‘9p21 loss’ mainly by perturbations in the tumor suppressor genes encoding cyclin-dependent kinase inhibitor 2A (CDKN2A) and S-methyl-5’-thioadenosine phosphorylase (MTAP). The latter resides 100 kb further away from CDKN2A and is co-deleted in 80–90% of cancers with CDKN2A deletion [12]. CDKN2A encodes the p14ARF and p16INK4A proteins, which signal through the p53 and retinoblastoma (Rb) protein pathways, respectively [13].
- 1
Address reprint requests to: Todd M. Savarese, Cancer Center, RM HB-774, University of Massachusetts Medical Center, 55 Lake Ave North, Worcester, MA 01655.
Copyright © 1996 Published by Elsevier Inc.