Trends in Pharmacological Sciences
ReviewMolecular biology of the aromatic hydrocarbon (dioxin) receptor
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2021, MitochondrionCitation Excerpt :Like the adaptive immune system, which is capable of recognizing and responding to a wide variety of antigens, chemical surveillance systems have evolved as mechanisms for recognizing a broad range of chemical structures and initiating appropriate responses (Hahn, 2002). Since its discovery in 1976 (Landers and Bunce, 1991), the biochemical, physicochemical, and recently, molecular properties of the AhR in rodents (and to a lesser extent, in humans) have been extensively characterized (Swanson and Bradfield, 1993; Hankinson, 1995; Jones et al., 1985; Nebert et al., 1993; Okey et al., 1994; Okey et al., 1994; Rowlands and Gustafsson, 1997; Schmidt and Bradfield, 1996; Higginbotham et al., 1968). Initially, scientists were intrigued by the extreme toxicity of chlorinated dibenzo-p-dioxins such as TCDD in animals (Schwetz et al., 1973; Poland and Glover, 1973).
The aryl hydrocarbon receptor: An environmental effector in the pathogenesis of fibrosis
2020, Pharmacological ResearchCitation Excerpt :The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a highly conserved transcription factor that is activated by environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [1], as well as small molecules provided by dietary, plant, or microbial metabolites [2]. AhR is widely expressed in various cell subsets and can involve in a variety of biological processes [2,3]. Although the function of AhR is not fully understood, evidence has shown that AhR regulates the cell cycle, tumorigenesis, the immune balance, and skin functions [4–6].
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