Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression
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Loss of the aryl hydrocarbon receptor increases tumorigenesis in p53-deficient mice
2022, Toxicology and Applied PharmacologyCitation Excerpt :The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor of the basic helix-loop-helix PER/ARNT/SIM (bHLH/PAS) family, is widely known for mediating the toxicity of exogenous compounds, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins (Hankinson, 1995; Hankinson et al., 1991; Denison and Whitlock Jr., 1995).
Oral benzo[a]pyrene administration attenuates dextran sulfate sodium-induced colitis in mice
2022, Chemico-Biological InteractionsCitation Excerpt :Apart from the effect on colitis, oral BaP administration exacerbates atherosclerosis and fatty liver in mouse models [11,12]. AHR activation has been considered as a cause of BaP-induced toxicity, because BaP toxicity is diminished in cells deficient in AHR function [26]. AHR-deficient mice are resistant to BaP-induced skin carcinogenesis [27].
Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice
2018, Food and Chemical ToxicologyIndoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor
2017, Toxicology and Applied PharmacologyCitation Excerpt :Error bars represent standard error of the mean (SEM). Mouse Hepa-1c1c7 cells and human HepG2 cells are commonly used in liver studies and were derived from a mouse and human hepatomas, respectively (Bernhard et al., 1973; Hankinson, 1979; Hankinson et al., 1991; Ihrke et al., 1993). The mouse H1L7.5c3 cell line variant was engineered by stable transfection of the pGudLuc7.5 plasmid into Hepa-1c1c7 cells (He et al., 2011) as was the HepG2 (40/6) cell line using pGudluc 6.1 and parental HepG2 cells (Long et al., 1998), in which both cell lines express an AHR-dependent, luciferase reporter gene system.
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters
2012, Biochemical Pharmacology