Quercetin-induced lipid peroxidation and DNa damage in isolated rat-liver nuclei
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A versatile flavonoid Quercetin: Study of its toxicity and differential gene expression in the liver of mice
2022, Phytomedicine PlusCitation Excerpt :In our previous in vivo studies, the acute doses of apigenin and genistein (flavonoids) elevated the serum biomarkers level which was partially mediated through oxidative stress (Singh et al., 2012, 2014). Considering the reports (Robaszkiewicz et al., 2007; Sahu and Washington, 1991; Soria et al., 2010) that quercetin may behave as a prooxidant and can cause oxidative stress to the cells, certain important oxidative stress parameters were evaluated. LPO and GSH are two important parameters which indicate the state of the cell in oxidative stress condition.
Quercetin: Prooxidant Effect and Apoptosis in Cancer
2018, Studies in Natural Products ChemistryCitation Excerpt :In this study, the most pronounced effect obtained using Ca2 + compared to Mg2 + was explained by the strong bonding of the latter causing stabilization of the reaction intermediates [52]. Sahu and coworkers demonstrated the degradation of DNA and lipid peroxidation by autoxidation caused by the incubation of hepatocyte nucleus from rats incubated with quercetin in the presence and absence of Cu2 +, and the latter caused a strong increase in the degradation process [53]. Oliveira and coworkers highlighted the mutagenic effect of quercetin in in vitro experiments and called attention to its autoxidation and consequent generation of ROS as a mechanism responsible for this biological effect [54].
Role of quercetin on Caco-2 cells against cytotoxic effects of alternariol and alternariol monomethyl ether
2016, Food and Chemical ToxicologyCitation Excerpt :However, there is also evidence of its prooxidative action (Durgo et al., 2007; Lombardi et al., 2012). Sahu and Washington (1991) and Soria et al. (2010) have found that the resultant prooxidant properties of Quer are responsible for its in vitro mutagenic and cytotoxic effects. Quer antioxidant and prooxidant effects largely relates to its dose in a given biological system.
Mechanistic network models in safety and toxicity evaluation of nutraceuticals
2016, Nutraceuticals: Efficacy, Safety and ToxicityPotential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow
2014, Toxicology ReportsCitation Excerpt :However, when quercetin exerts its antioxidant effect, it may be converted into potentially harmful oxidation products or subjected to in vitro oxidative degradation, resulting in the formation of an ortho-quinone and the subsequent production of ROS, such as superoxide and hydrogen peroxide (H2O2) [23]. The resultant prooxidant properties of quercetin are responsible for its in vitro mutagenic and cytotoxic effects [24,25]. Whether quercetin exerts antioxidant and prooxidant effects largely relates to its dose in a given biological system [26] and can be revealed by determining changes in the level of oxidative stress in the system when quercetin is added at different doses.