Elsevier

Neuroscience Letters

Volume 91, Issue 2, 31 August 1988, Pages 172-176
Neuroscience Letters

Pharmacological evidence that somatostatin activates the m-current in hippocampal pyramidal neurons

https://doi.org/10.1016/0304-3940(88)90763-XGet rights and content

Abstract

In the in vitro hippocampal slice somatostatin has been shown to cause a direct hyperpolarization of CA1 pyramidal neurons by increasing a potassium conductance which is resistant to blockade by tetraethylammonium, 4-aminopyridine, or cesium ions. Results reported here demonstrate that this somatostatin-induced hyperpolarization is blocked by 1 mM barium and 5 × 10−5 M carbachol, with the action of carbachol being reversed by atropine. Barium and carbachol both inactivate the m-current and these results suggest that somatostatin may exert its hyperpolarizing action on CA1 pyramidal cells by activation of the m-current.

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