Hyposmolarity-activated fluxes of taurine in astrocytes are mediated by diffusion
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Cited by (85)
Astrocyte activation and reactive gliosis—A new target in stroke?
2019, Neuroscience LettersCitation Excerpt :The unique ability of astrocytes to respond to hypoosmotic environment by transient swelling and their tendency to assume their original cell volume [60] is called a regulatory volume decrease and involves an efflux of osmotically active molecules, e.g. taurine from astrocytes [61–63]. Regulatory volume decrease by astrocytes is a key mechanism in counteracting the development of brain edema due to ischemia or trauma, conceivably with cytoskeleton‐linked stretch‐activated plasma membrane channels acting as cell‐volume sensors [64–67]. Indeed, intermediate-filament-fee astrocytes subjected to hypoosmotic stress exhibit about 50% reduction in taurine release compared to wild‐type astrocytes [68].
Intermediate filaments and stress
2007, Experimental Cell ResearchStress models for the study of intermediate filament function
2004, Methods in Cell BiologyCitation Excerpt :The consequences of osmotic stress are particularly harmful in the CNS because of the lack of expansion space. The regulatory volume decrease by astrocytes might be a key mechanism in counteracting the development of brain edema in situations of ischemia or trauma, and it has been proposed that the sensors for cell volume might be cytoskeleton-linked stretch-activated plasma membrane channels (Cantiello, 1997; Cantiello et al., 1993; Moran et al., 1996; Sanchez-Olea et al., 1991). Ding and coworkers subjected primary astrocyte cultures from wild-type, GFAP−⧸−, Vim−⧸−, and GFAP−⧸−Vim−⧸− mice to hypoosmotic stress (corresponding to 25 mM reduction in NaCl) in perfusion chambers and assessed subsequent efflux of 3H-taurine.
Reduction of phospholemman expression decreases osmosensitive taurine efflux in astrocytes
2001, Biochimica et Biophysica Acta - Molecular Cell ResearchNucleoside transport inhibition in ischemic myocardium results in enhanced taurine efflux
2001, European Journal of PharmacologyModulation of taurine release by glutamate receptors and nitric oxide
2000, Progress in Neurobiology