Cellular expression of α4 subunit mRNA of the nicotinic acetylcholine receptor in the developing rat telencephalon☆
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Cited by (19)
Cholinergic influences on cortical development and adult neurogenesis
2011, Behavioural Brain ResearchCitation Excerpt :Neuronal nicotinic acetylcholine (ACh) receptors belong to the family of excitatory ligand-gated channels and are pentameric assembled from different combinations of 12 different subunits. Nicotinic receptor subunit mRNAs appear from mid to late embryogenesis throughout the rat cerebral cortex and hence precede the cholinergic innervation from the basal forebrain [8,99,145]. Muscarinic receptors on the other hand are G-protein coupled and appear later.
Structural determinants of the roles of acetylcholine in cerebral cortex
2004, Progress in Brain ResearchCitation Excerpt :It makes it unlikely that transient, ‘instructive’ synapses are being established by the growing ACh neurons. Even though the subcellular distribution of ACh receptors in the developing cortex has not yet been determined, functional receptors of both the nicotinic and muscarinic families are known to be expressed by cortical cells in the late embryonic and early postnatal periods (Ostermann et al., 1995; Zoli et al., 1995; Aubert et al., 1996; Ma et al., 2000; see also Chapter 1). Thus, diffuse transmission and an ambient level of ACh, as discussed above, could participate in the many roles attributed to ACh during corticogenesis (Bear and Singer, 1986; Broide et al., 1996; Zhu and Waite, 1998; Aramakis et al., 2000; Peinado, 2000).
Expression of the α4 isoform of the nicotinic acetylcholine receptor in the fetal human cerebral cortex
2001, Developmental Brain ResearchSurvival and mitogenesis of neuroepithelial cells are influenced by noradrenergic but not cholinergic innervation in cultured embryonic rat neopallium
2000, Brain ResearchCitation Excerpt :Experimental elimination of this projection results in altered neuronal migration patterns amongst lower cortical laminae in neonates [15]. However, appearance of muscarinic binding sites [34] and expression of nicotinic receptor subunits [29] occurs throughout all the layers of rat cortex in foetal life, and muscarinic (principally m3) receptor activation promotes the survival of neurons which develop in both postnatal [41] and prenatal periods [24]. Neural precursor cells in the rat foetal cortex express ChAT [7], but it has not been established whether these cells can release acetylcholine locally to activate its receptors.
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This study was supported by the Deutsche Forschungsgemeinschaft (Schr 283/8-2).
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We are greatly indebted to Prof. S. Heinemann, La Jolla, for providing the clones used for probe construction. We would like to thank Prof. P.G.M. Luiten, Groningen, for valuable comments. We thank A. Jeske, S. Nowacki and K. Pilz for excellent technical assistance, I. Koch for photographical and A. Kirchmayer for secretarial work.