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2018, Progress in Retinal and Eye ResearchCitation Excerpt :Studies of other tissues revealed widespread distribution of Sig1Rs throughout the body including heart (Novakova et al., 1995), liver and kidney (Seth et al., 1998; Hellewell et al., 1994), spleen (Wolfe et al., 1997) and reproductive organs (Matsuno et al., 1993). The earliest hint that Sig1Rs were expressed in tissues related to the visual system, came in the late 1980's with autoradiographic detection of Sig1R in the lateral geniculate nucleus and superior colliculus (McLean and Weber, 1988). Shortly thereafter, Schoenwald and colleagues used radiolabeled pharmacologic methods and demonstrated the presence of Sig1R in lacrimocytes isolated from the rabbit lacrimal gland (Schoenwald et al., 1993; Shirolkar et al., 1993).
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2018, Pharmacology and TherapeuticsCitation Excerpt :The role of σRs in dopaminergic neurotransmission has been of interest since early findings that antipsychotics and other drugs involved in dopaminergic signaling have affinity for σRs (Iyengar et al., 1990; Wachtel & White, 1988). σRs are expressed in dopaminergic regions including the striatum, substantia nigra (SN), and ventral tegmental area (VTA) (Gundlach, Largent, & Snyder, 1986; Hayashi et al., 2010; McLean & Weber, 1988). Using immunohistochemistry, σ1Rs were identified in dopaminergic neurons (Francardo et al., 2014).
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2016, Pharmacology and TherapeuticsMethamphetamine-induced toxicity: An updated review on issues related to hyperthermia
2014, Pharmacology and TherapeuticsCitation Excerpt :METH interacts with sigma receptors at micromolar concentrations that can be achieved under physiological conditions (Nguyen et al., 2005). These proteins are found in the hypothalamus, as well as the cardiovascular system (McLean & Weber, 1988; Ela et al., 1994; Zhang & Cuevas, 2002; Tagashira et al., 2010). Pretreatment of mice with selective sigma receptor putative antagonists, including AC927, AZ66, CM156, and SN79, significantly attenuates METH-induced hyperthermia (Matsumoto et al., 2008; Kaushal et al., 2011; Seminerio et al., 2011, 2012; Kaushal et al., 2013; Robson et al., 2013; Seminerio et al., 2013).