Multiple actions of arylalkylamine arthropod toxins on theN-methyl-d-aspartate receptor
References (43)
- et al.
Structures and biological activities of three synaptic antagonists from orb weaver spider venom
Biochem. biophys. Res. Commun.
(1987) - et al.
Spider toxin blocks excitatory amino acid responses in isolated hippocampal pyramidal neurons
Neurosci. Lett.
(1987) - et al.
Spermine and philanthotoxin potentiate excitatory amino acid responses ofXenopus oocytes injected with rat and chick brain RNA
Neurosci. Lett.
(1990) - et al.
GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses
Neuron
(1993) - et al.
Argiotoxin636 inhibits NMDA-activated ion channels expressed inXenopus oocytes
Neurosci. Lett.
(1991) - et al.
Effects of philanthotoxin-343 on CA1 pyramidal neurons of rat hippocampusin vitro
Eur. J. Pharmac.—Environ. Toxic. Pharmac. Sect.
(1992) - et al.
Argiotoxin detects molecular differences in AMPA receptor channels
Neuron
(1993) - et al.
Spider toxins as tools for dissecting elements of excitatory amino acid transmission
Trends Neurosci.
(1988) Spermine regulatesN-methyl-d-aspartate receptor desensitization
Neuron
(1992)- et al.
Spermine reciprocally changes the affinity of NMDA receptor agonists and antagonists
Eur. J. Pharmac.—Molec. Pharmac. Sect.
(1991)
Subunit-specific block of cloned NMDA receptors by argiotoxin636
Fedn Eur. biochem. Socs Lett.
1,10-diaminodecane and 1,12-diaminododecane block NMDA receptor currents by an open channel mechanism
Neurosci. Lett.
Histamine potentiatesN-methyl-d-aspartate responses in acutely isolated hippocampal neurons
Neuron
Multiple effects of spermine onN-methyl-d-aspartic acid receptor responses of rat cultured hippocampal neurones
J. Physiol., Lond.
A single amino acid determines the subunit-specific spider toxin block of α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels
Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins
J. Pharmac. exp. Ther.
Splice variants of theN-methyl-d-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C
Structure and synthesis of a potent glutamate receptor antagonist in wasp venom
Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: anin situ hybridization study
J. Neurosci.
Block ofN-methyl-d-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels
Philanthotoxin blocks quisqualate-, AMPA- and kainate-, but not NMDA-, induced excitation of rat brainstem neuronesin vivo
Br. J. Pharmac.
Cited by (26)
Pregabalin is a potent and selective ligand for α <inf>2</inf>δ- 1 and α <inf>2</inf>δ-2 calcium channel subunits
2011, European Journal of PharmacologyCitation Excerpt :Cortical cells were cultured from 18-day-old Sprague–Dawley rat fetuses (Charles River Labs International Inc., Portage, MI, USA) and used 1–2 weeks after plating. Recordings were carried out at room temperature (23 °C) according to previously described techniques (Donevan and Rogawski, 1996) in a control bathing solution containing 142 mM NaCl, 1.5 mM KCl, 0.1 mM CaCl2, 10 mM HEPES, 10 mM glucose, and 20 mM sucrose (320 mOsm, pH 7.4). The bathing solution also contained 200–500 nM of tetrodotoxin to block voltage-gated sodium channels.
Argiotoxin 636
2007, xPharm: The Comprehensive Pharmacology ReferenceVoltage-dependent blockade of connexin40 gap junctions by spermine
2003, Biophysical JournalCitation Excerpt :Because free polyamine levels can be increased by lowering ATP levels or increasing ornithine decarboxylase activity, spermine block of Cx40 gap junctions could have a more prominent role in cardiac hypertrophy, myocardial ischemia, and β-adrenergic stimulation induced arrhythmias (Nichols et al., 1996; Bergeron et al., 1998). Natural spermine analogs are found in certain spider and wasp venoms and likely exert their toxic effects on neuronal NMDA and nicotinic acetylcholine receptor channels in addition to the inward rectifier K+ channels (Donevan and Ragowski, 1996; Nichols et al., 1996; Haghighi and Cooper, 1998; Ruppersberg, 2000). These polyamine-related toxins typically have a large hydrophobic headgroup that prevents them from traversing the cell membrane or the channel pore and thus act extracellularly.
IgG isolated from LP-BM5 infected mouse brain activates ionotropic glutamate receptors
2001, Neurobiology of DiseaseEffect of two polyamine toxins on the bacterial porin OmpF
2001, Biochemical and Biophysical Research Communications