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Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A
2017, Journal of Biological ChemistryIs lesion-induced synaptic rewiring driven by activity homeostasis?
2017, The Rewiring Brain: A Computational Approach to Structural Plasticity in the Adult BrainThe ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons
2015, Molecular and Cellular NeuroscienceCitation Excerpt :Development of stable dendritic spines in excitatory neurons follows at least two mechanisms (Dailey and Smith, 1996). In the first week of postnatal brain development, highly dynamic and predominant dendritic filopodia form immature axo-dendritic contacts with the axons that innervate the dendritic fields (Fiala et al., 1998; Papa and Segal, 1996; Ziv and Smith, 1996). Some of these immature synaptic contacts are stabilized and then differentiate in morphological and functional bulbous-head containing mature spine synapses through a coordinated assembly of protein scaffolds and precursor vesicles at the pre- and postsynaptic regions (Lohmann and Bonhoeffer, 2008; Marrs et al., 2001; Okabe et al., 2001; Sytnyk et al., 2004) and by the recruitment of intercellular adhesion proteins (Arstikaitis et al., 2011; Sytnyk et al., 2004; Yoshihara et al., 2009).
Cyclin-dependent kinase 5 (Cdk5)-dependent phosphorylation of p70 ribosomal S6 kinase 1 (S6K) is required for dendritic spine morphogenesis
2015, Journal of Biological ChemistryADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity
2015, Journal of Biological ChemistryCitation Excerpt :We found that TTX treatment completely blocked the spine-promoting effect of ARF6-T157A, inducing longer thin spinelike protrusions (Fig. 6 A). To verify whether the effect of ARF6 on spine formation in mature neurons is dependent on neuronal activity, we treated mature neurons with PTX, a noncompetitive antagonist for the GABAA receptor, thus increasing neuronal activity (38). We discovered that PTX treatment completely blocked the spine-reducing effect of ARF6-T157A in mature neurons (Fig. 6D).
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Present address: Department of Human Anatomy, Second University of Napoli, Napoli, Italy.