Role of glutathione S-transferase isoenzymes in cisplatin-induced nephrotoxicity in the rat
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2022, Life SciencesCitation Excerpt :Toxic, highly reactive oxygen free radicals are induced by cisplatin, which causes a rise in lipid peroxidation and a decrease in the enzyme activity that protects the body from lipid peroxidation as well as a reduction in the body's antioxidant status and results in nephrotoxicity [84–86]. Furthermore, reactive nitrogen species have been linked to the mechanism of nephrotoxicity induced by cisplatin, which is characterized by a rise in renal peroxynitrite and nitric oxide levels [87,88]. By oxidizing thiol pools, peroxynitrite induces alterations in the structure and function of proteins, chemical breakage of DNA, lipid peroxidation, and a loss in cellular defenses.
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2004, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In this study, cisplatin alone had no significant effect on GST activity in renal cortex homogenate. Previous studies have associated cisplatin nephrotoxicity with a decrease in GST activity (GST-α, GST-μ levels) in kidney cortex and with an increase in urinary GST activity [35,36]. The stable level of GST activity in renal cortex homogenate in our study may be explained by differences in treatment regimens and doses.
Cisplatin up-regulates the adenosine A<inf>1</inf> receptor in the rat kidney
2002, European Journal of PharmacologyGlutathione S-transferases as biomarkers of organ damage: Applications of rodent and canine GST enzyme immunoassays
1998, Chemico-Biological InteractionsProtection against cisplatin-induced nephrotoxicity in the rat by inducers and an inhibitor of glutathione S-transferase
1994, Biochemical Pharmacology