Journal of Chromatography B: Biomedical Sciences and Applications
Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma
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Cited by (121)
Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence
2020, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :This hydrolysis depends mainly on pH: at pH less than 5 the lactone form is favored, while at pH > 9 the carboxylate form is formed [2,13,14]. Only the lactone form can bind the topoisomerase I, however, it has been previously described that the quantification of the lactone and carboxylate forms (total irinotecan and SN-38), is as clinically relevant as the quantification of the lactone form, since the pharmacokinetics of both forms is correlated [2,15,16]. The typical chromatograms obtained after spiking the analytes and internal standard in human plasma at the lower and upper limit of quantification are shown in Fig. 2 (A and B, respectively).
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2020, Carbohydrate PolymersSecond-order calibration method applied to process three-way excitation-emission-kinetic fluorescence data: A novel tool for real-time quantitative analysis of the lactone hydrolysis of irinotecan in human plasma
2015, Chemometrics and Intelligent Laboratory SystemsCitation Excerpt :Moreover, these compounds can also undergo other metabolic transformations (apart from lactone hydrolysis) or be present within complex background; thus, the method used to monitor hydrolysis should be general enough to differentiate between the lactone and carboxylate forms of the drug, even if other metabolic changes or complex background interferences occur. To date, several reports have described the hydrolysis and lactonization reactions of CPTs measured by ultraviolet spectrometry (UV–vis) and spectrofluorimetry [11–13], capillary zone electrophoresis [14], high-performance liquid chromatography (HPLC) with ultraviolet [15], fluorescence detection [16, 17], and mass spectrometry [5]. The above methods are indeed useful for measuring the rates of hydrolysis and lactonization.
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2013, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :Although it is uncertain why these values significantly deviated only in the High QC sample of irinotecan, we presumed that the pH of the mobile phase and stock solutions might have been affected. In solution, the lactone ring of irinotecan is in equilibrium with the open-ring carboxylate form, and mobile phase pH and solution concentration can significantly distort its analysis [23–25]. The deviation of the High QC irinotecan sample was unfortunate, however, an analysis in the low concentration range is potentially more relevant to occupational exposure studies [26].