Neuron
ArticleRepulsion between tetraethylammonium ions in cloned voltage-gated potassium channels
References (40)
- et al.
Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits
Neuron
(1990) - et al.
How might the diversity of potassium channels be generated?
Trends Neurosci.
(1990) - et al.
Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels
J. Biol. Chem.
(1991) - et al.
Binding of thallium and other cations to the gramicidin A channel: equilibrium dialysis study of gramicidin in phosphatidylcholine vesicles
J. Mol. Biol.
(1980) - et al.
Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore
J. Physiol.
(1984) - et al.
The mechanism of ion selectivity in calcium channels of skeletal muscle membrane
Prog. Zool.
(1986) Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons
J. Gen. Physiol.
(1969)Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons
J. Gen. Physiol.
(1971)- et al.
Block of squid axon K+ channels by internally and externally applied barium ions
J. Gen. Physiol.
(1982) - et al.
Ion conductance and selectivity of single calcium-activated potassium channels in cultured rat muscle
J. Gen. Physiol.
(1984)
Simplified gene nomenclature
Nature
Expression of a cloned rat brain potassium channel in Xenopus oocytes
Science
Pursuing the structure and function of voltage-gated channels
Trends Neurosci.
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
Pflügers Arch.
Exchange of conduction pathways between two related K+ channels
Science
Mechanism of ion permeation through calcium channels
Nature
The selective inhibition of delayed potassium currents in nerve by tetraethylammonium ion
J. Gen. Physiol.
Mechanisms of block
Ion movements in pores formed by gramicidin A
The potassium permeability of a giant nerve fibre
J. Physiol.
Cited by (32)
Trans-channel interactions in batrachotoxin-modified skeletal muscle sodium channels: Voltage-dependent block by cytoplasmic amines, and the influence of μ-conotoxin GIIIA derivatives and permeant ions
2008, Biophysical JournalCitation Excerpt :Amine blockers such as tetra-alkyl ammonium ions (TAA1–5) are known to be internal blockers of voltage-gated sodium channels (5,26–28), as well as internal (29–31) and, in some cases, external (32) blockers of voltage-gated potassium channels. Electrostatic repulsion is widely suggested to occur between conducting or blocking ions in KV and CaV channels (32–35). An electrostatic interaction might also occur between the two blockers when they occupy sites in close proximity within the NaV pore (6).
Mechanisms of tetraethylammonium ion block in the KcsA potassium channel
2001, FEBS LettersIonic blockade of the rat connexin40 gap junction channel by large tetraalkylammonium ions
2001, Biophysical JournalCitation Excerpt :The TPeA+ and THxA+ block and unblock data indicate that unblock is more rapid than block. Hence, bilateral addition of TAA+ will not provide an accurate test of the one-site or two-site models unless interactions are observed between bilateral [TAA+] as reported for voltage-gated potassium channels (Newland et al., 1992). To test this hypothesis, 500 μM TPeA+ or 2 mM TPeA+ was added to the trans side relative to 2 mM TPeACl.
Chapter 4 Permeation of Voltage-Dependent Potassuim Channels
1999, Current Topics in Membranes and Transport
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Present address: Neuroscience Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, England.