Neuron
Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons
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Cited by (133)
An improved measurement of the Ca<sup>2+</sup>-binding affinity of fluorescent Ca<sup>2+</sup> indicators
2018, Cell CalciumCitation Excerpt :Although this study measured Kd of fluorescent Ca2+ dyes in vitro, it should provide reasonable estimates of the respective Kd in neurons. We found that the Kd values of both OGB-6F and OGB-1 were not significantly affected by addition of ∼0.7 mM Mg2+, a concentration observed in neurons ([40–42]; Figs. 1B vs. 2B and data not shown). This suggests that these dyes have a relatively low affinity for Mg2+, most likely similar to that of fura-2 and fluo-3 (i.e Kd ≥ 5 mM; [34,43]).
Neural depolarization triggers Mg<sup>2+</sup> influx in rat hippocampal neurons
2015, NeuroscienceCitation Excerpt :However, little is known about [Mg2+]i changes under physiological conditions in healthy neurons. Previous studies reported, in neurons loaded with mag-fura-2, a Mg2+ mobilization elicited by glutamate and veratridine (Brocard et al., 1993) and neuronal depolarizer, a high concentration of KCl (Kato et al., 1998; Gotoh et al., 1999). The [Mg2+]i imaging, using a conventional Mg2+ probe, should be carefully performed in cells with the wide dynamic range of intracellular calcium ion concentration ([Ca2+]i) increase by using Mg2+ probes with low selectivity (Stout and Reynolds, 1999).
Hypoxia induces an increase in intracellular magnesium via Transient Receptor Potential Melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro
2011, Journal of Biological ChemistryCitation Excerpt :The different time phase of these two important cations implied there may be some kind of interaction. It has been reported that glutamate caused a large increase in [Mg2+]i through a Ca2+ influx in cerebral neurons (29), and an intracellular Mg2+ surge followed Ca2+ increase during depolarization in cultured neurons (37). According to the time window differences and the reports above, it is accepted that [Ca2+]i overload may contribute to the [Mg2+]i overload to a certain degree in OGD/CI and that needs our further investigation.
cNTnC and fYTnC2, Genetically Encoded Green Calcium Indicators Based on Troponin C from Fast Animals
2022, International Journal of Molecular Sciences
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The first two authors contributed equally to this work.