Neuron
ArticleSteady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes
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2018, NeuropharmacologyCitation Excerpt :The first of these, the neuronal transporter GAT-1, was cloned by Guastella et al., 1990. It transports 2Na+ ions for each GABA molecule and hence is electrogenic, i.e., generates an inward current accompanying GABA uptake (Mager et al., 1993). This would explain why raising external K+ stimulated efflux (Bowery et al., 1979b): the depolarization would reduce the uptake rate and favour a GABA counter-efflux.
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