Neuron
Volume 10, Issue 2, February 1993, Pages 317-326
ArticleFunctional expression of sodium channel mutations identified in families with periodic paralysis
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2008, Advances in GeneticsCitation Excerpt :Expression studies showed that both mutations disrupted inactivation without affecting single channel conductance. The Thr704Met mutation displayed late first openings, prolonged open times, and shifted the voltage dependence of activation toward negative potentials (Cannon, 2006; Cannon et al., 1993). This mutation also modified the slow inactivation.
Copyright © 1993