Elsevier

Epilepsy Research

Volume 2, Issue 3, May–June 1988, Pages 145-181
Epilepsy Research

Review article
Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

https://doi.org/10.1016/0920-1211(88)90054-XGet rights and content

First page preview

First page preview
Click to open first page preview

References (192)

  • W. Löscher

    Anticonvulsant action in the epileptic gerbil of novel inhibitors of GABA uptake

    Eur. J. Pharmacol.

    (1985)
  • W. Löscher

    Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsyprone gerbils

    Pharmacol. Biochem. Behav.

    (1986)
  • W. Löscher et al.

    Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats

    Exp. Neurol.

    (1985)
  • W. Löscher et al.

    Development of tolerance to the anticonvulsant effect of diazepam in amygdalakindled rats

    Exp. Neurol.

    (1985)
  • W. Löscher et al.

    Is amygdalakindling in rats a model for drug-resistant partial epilepsy?

    Exp. Neurol.

    (1986)
  • W. Löscher et al.

    Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy

    Eur. J. Pharmacol.

    (1984)
  • W. Löscher et al.

    Evaluation of differentβ-carbolines in Mongolian gerbils with reflex epilepsy

    Eur. J. Pharmacol.

    (1985)
  • W.J. Loskota et al.

    The Mongolian gerbil (Meriones unguiculatus) as a model for the study of the epilepsies: EEG records of seizures

    Electroenceph. Clin. Neurophysiol.

    (1975)
  • T.E. Albertson et al.

    Anticonvulsant drugs and their antagonism of kindled amygdaloid seizures in rats

    Neuropharmacology

    (1980)
  • P.S. Albright et al.

    Development of a new pharmacological seizure model: effects of anticonvulsants on cortical- and amygdala-kindled seizures in the rat

    Epilepsia

    (1980)
  • C. Aldinio et al.

    Experimental models of aging and quinolinic acid

    Meth. Find. Exp. Clin. Pharmacol.

    (1985)
  • D. Ashton et al.

    Behavioral analysis of the effects of 15 anticonvulsants in the amygdaloid kindled rats

    Psychopharmacology (Berl.)

    (1979)
  • B. Ault et al.

    Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome

    J. Pharmacol. Exp. Ther.

    (1986)
  • V. Baltzer et al.

    Experimental anticonvulsive properties of GP 47 680 and of GP 47 779, its main human metabolite; compounds related to carbamazepine

  • G.D. Bartoszyk et al.

    Gabapentin

  • J.-R. Boissier et al.

    Une nouvelle méthode simple pour explorer l'action ‘tranquillisante’: le test de la cheminée

    Méd. Exp. (Basel)

    (1960)
  • W.C. Buhles et al.

    Nafimidone

  • J.P. Chambon et al.

    CM 40907 and SR 41378: two piperidino-pyridazine derivatives

  • A.G. Chapman et al.

    Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures

    Arzneim.-Forsch.

    (1984)
  • R.L. Collins

    Audiogenic seizures

  • Commission on Classification and Terminology of the In- ternational League Against Epilepsy

    Proposal for revised clinical and electroencephalographic classification of epileptic seizures

    Epilepsia

    (1981)
  • Commission on Classification and Terminology of the In- ternational League Against Epilepsy

    Proposal for classification of epilepsies and epileptic syndromes

    Epilepsia

    (1985)
  • P. Consroe et al.

    Audiogenic seizure susceptible rats

  • L.L. Coughenor et al.

    A new device for the rapid measurement of impaired motor function in mice

    Pharmacol., Biochem. Behav.

    (1977)
  • C.R. Craig

    Evidence for a role of neurotransmitters in the mechanism of topical convulsant models

  • S.M. Crain

    Tissue culture models of epileptiform activity

  • R.D. Crawford

    A new mutant causing epileptic seizures in domestic fowls

    Poultry Sci.

    (1969)
  • P. Crawford et al.

    A comparative study of progabide, valproate and placebo as add-on therapy in patients with refractory epilepsy

    J. Neurol. Neurosurg. Psychiat.

    (1986)
  • M.J. Croucher et al.

    Anticonvulsant action of excitatory amino acid antagonists

    Science

    (1982)
  • D.R. Curtis

    Microiontophoretic studies of single neurons

  • M. Dam et al.

    GABA-agonists in the treatment of epilepsy

    Acta Neurol. Scand.

    (1982)
  • H.L. Edmonds et al.

    Anticonvulsant properties of rozipine in epileptic and nonepileptic beagle dogs

    Epilepsia

    (1978)
  • J. Engel et al.

    Potential relevance of kindling to human partial epilepsy

  • Esquirol, 1815

  • R.G. Fariello et al.

    A double-blind, placebo controlled trial of progabide in epilepsy

    Neurology

    (1987)
  • J.E. Fisher et al.

    The spontaneous seizure genotype sz in hamsters as a disease model of benzodiazepine receptor deficits

  • H.-H. Frey

    Primidone

  • H.-H. Frey

    Experimental evidence for the development of tolerance to anticonvulsant drug effects

  • H.-H. Frey et al.

    Anticonvulsant potency of common antiepileptic drugs in the gerbil

    Pharmacology

    (1983)
  • W. Fröscher et al.

    Development of tolerance to the anticonvulsant effects of flunarizine and its side effects? Clinical, psychometric, EEG and biochemical approaches

  • Cited by (772)

    • The novel dual-mechanism Kv7 potassium channel/TSPO receptor activator GRT-X is more effective than the Kv7 channel opener retigabine in the 6-Hz refractory seizure mouse model

      2022, Neuropharmacology
      Citation Excerpt :

      In the traditional MES test, which has been used over several decades as the major gatekeeper for ASD discovery (before it was partially replaced by the 6-Hz model) (Bialer and White, 2010: Löscher, 2017), GRT-X exhibited similar potency to block seizures than retigabine. However, in the ECS threshold test, which is more sensitive to identify antiseizure activity than the MES with its suprathreshold current (Löscher and Schmidt, 1988), GRT-X was much more effective to increase seizure threshold than retigabine. In contrast, GRT-X was clearly less effective than retigabine in the s.c. PTZ seizure test and the timed i.v. PTZ seizure threshold model.

    View all citing articles on Scopus
    View full text