Review articleWhich animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations
References (192)
- et al.
Pharmacological modification of amygdaloid-kindled seizures
Neuropharmacology
(1980) - et al.
Phosphonic analogues of excitatory amino acids raise the threshold for maximal electroconvulsions in mice
Neurosci. Res.
(1985) - et al.
A note on a simple apparatus for detecting neurological deficit in rats and mice
J. Am. Pharm. Ass.
(1957) - et al.
The THIP-induced model of bilateral synchronous spike and wave in rodents
Neuropharmacology
(1987) - et al.
A permanent change in brain function resulting from daily electrical stimulation
Exp. Neurol.
(1969) - et al.
Antagonism of gamma-hydroxybutyrate-induced hypersynchronization in the ECoG of the rat by anti-petit mal drugs
Neurosci. Lett.
(1976) - et al.
Gamma-vinyl GABA
Gen. Pharmacol.
(1985) What triggers seizures in the gerbil, Meriones unguiculatus?
Life Sci.
(1975)Comparative assay of anticonvulsant and toxic potencies of sixteen GABA-mimetic drugs
Neuropharmacohgy
(1982)Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice
Biochem. Pharmacol.
(1982)
Anticonvulsant action in the epileptic gerbil of novel inhibitors of GABA uptake
Eur. J. Pharmacol.
(1985)
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsyprone gerbils
Pharmacol. Biochem. Behav.
(1986)
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats
Exp. Neurol.
(1985)
Development of tolerance to the anticonvulsant effect of diazepam in amygdalakindled rats
Exp. Neurol.
(1985)
Is amygdalakindling in rats a model for drug-resistant partial epilepsy?
Exp. Neurol.
(1986)
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy
Eur. J. Pharmacol.
(1984)
Evaluation of differentβ-carbolines in Mongolian gerbils with reflex epilepsy
Eur. J. Pharmacol.
(1985)
The Mongolian gerbil (Meriones unguiculatus) as a model for the study of the epilepsies: EEG records of seizures
Electroenceph. Clin. Neurophysiol.
(1975)
Anticonvulsant drugs and their antagonism of kindled amygdaloid seizures in rats
Neuropharmacology
(1980)
Development of a new pharmacological seizure model: effects of anticonvulsants on cortical- and amygdala-kindled seizures in the rat
Epilepsia
(1980)
Experimental models of aging and quinolinic acid
Meth. Find. Exp. Clin. Pharmacol.
(1985)
Behavioral analysis of the effects of 15 anticonvulsants in the amygdaloid kindled rats
Psychopharmacology (Berl.)
(1979)
Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome
J. Pharmacol. Exp. Ther.
(1986)
Experimental anticonvulsive properties of GP 47 680 and of GP 47 779, its main human metabolite; compounds related to carbamazepine
Gabapentin
Une nouvelle méthode simple pour explorer l'action ‘tranquillisante’: le test de la cheminée
Méd. Exp. (Basel)
(1960)
Nafimidone
CM 40907 and SR 41378: two piperidino-pyridazine derivatives
Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures
Arzneim.-Forsch.
(1984)
Audiogenic seizures
Proposal for revised clinical and electroencephalographic classification of epileptic seizures
Epilepsia
(1981)
Proposal for classification of epilepsies and epileptic syndromes
Epilepsia
(1985)
Audiogenic seizure susceptible rats
A new device for the rapid measurement of impaired motor function in mice
Pharmacol., Biochem. Behav.
(1977)
Evidence for a role of neurotransmitters in the mechanism of topical convulsant models
Tissue culture models of epileptiform activity
A new mutant causing epileptic seizures in domestic fowls
Poultry Sci.
(1969)
A comparative study of progabide, valproate and placebo as add-on therapy in patients with refractory epilepsy
J. Neurol. Neurosurg. Psychiat.
(1986)
Anticonvulsant action of excitatory amino acid antagonists
Science
(1982)
Microiontophoretic studies of single neurons
GABA-agonists in the treatment of epilepsy
Acta Neurol. Scand.
(1982)
Anticonvulsant properties of rozipine in epileptic and nonepileptic beagle dogs
Epilepsia
(1978)
Potential relevance of kindling to human partial epilepsy
Esquirol, 1815
A double-blind, placebo controlled trial of progabide in epilepsy
Neurology
(1987)
The spontaneous seizure genotype sz in hamsters as a disease model of benzodiazepine receptor deficits
Primidone
Experimental evidence for the development of tolerance to anticonvulsant drug effects
Anticonvulsant potency of common antiepileptic drugs in the gerbil
Pharmacology
(1983)
Development of tolerance to the anticonvulsant effects of flunarizine and its side effects? Clinical, psychometric, EEG and biochemical approaches
Cited by (772)
The novel dual-mechanism Kv7 potassium channel/TSPO receptor activator GRT-X is more effective than the Kv7 channel opener retigabine in the 6-Hz refractory seizure mouse model
2022, NeuropharmacologyCitation Excerpt :In the traditional MES test, which has been used over several decades as the major gatekeeper for ASD discovery (before it was partially replaced by the 6-Hz model) (Bialer and White, 2010: Löscher, 2017), GRT-X exhibited similar potency to block seizures than retigabine. However, in the ECS threshold test, which is more sensitive to identify antiseizure activity than the MES with its suprathreshold current (Löscher and Schmidt, 1988), GRT-X was much more effective to increase seizure threshold than retigabine. In contrast, GRT-X was clearly less effective than retigabine in the s.c. PTZ seizure test and the timed i.v. PTZ seizure threshold model.
Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies
2023, International Journal of Molecular Sciences
Copyright © 1988 Published by Elsevier B.V.