European Journal of Pharmacology: Molecular Pharmacology
The cloned dopamine D2 receptor reveals different densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography
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Cited by (66)
Schizophrenia thalamus imaging: Low benzamide binding to dopamine D2 receptors suggests fewer D2Short receptors and fewer presynaptic terminals
2013, Psychiatry Research - NeuroimagingCitation Excerpt :A third possible explanation is that the spiperone ligands and the benzamide ligands bind to different aspects of the D2 receptors. For example, the spiperone ligands bind to monomers of D2, while the benzamides bind to dimers or multimers of D2 receptors (Seeman et al., 1992; Zawarynski et al., 1998). For example, nemonapride (also known as emonapride), as well as raclopride, are benzamide antipsychotic drugs that consistently detect 50% more dopamine D2 receptors than spiperone in the same tissue, including the cloned D2 receptor (Seeman et al., 1992).
Pharmacology of signaling induced by dopamine D<inf>1</inf>-like receptor activation
2010, Pharmacology and TherapeuticsAntagonist-radioligand binding to D<inf>2L</inf>-receptors in intact cells
2008, Biochemical PharmacologyCitation Excerpt :That binding of [3H]-spiperone to intracellular D2L-receptors might be reflected as non-specific binding is unlikely since, in the present study, it was similar to the total (and non-displaceable) [3H]-spiperone binding in the parent CHO-AEQ cells. Studies with cell membrane preparations yield distinct D2-receptor binding capacities when comparing radiolabelled benzamides and butyrophenones [24,28,37,38]. However, this could reflect the ionic composition of the incubation medium.
Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D<inf>2</inf>-receptor occupancy method in the rat
2006, European Journal of Pharmacology(-)S amisulpride binds with high affinity to cloned dopamine D<inf>3</inf> and D<inf>2</inf> receptors
2001, European Journal of PharmacologyDopamine D<inf>2</inf> receptor dimer formation. Evidence from ligand binding
2001, Journal of Biological ChemistryCitation Excerpt :The model may also explain some other phenomena that have been observed for the D2 dopamine receptor such as the observation of two rates of radioligand dissociation (31, 45), the complex pH dependence of the binding of some ligands (46), and the pseudocompetition of amiloride analogues versus [3H]spiperone binding with Hill coefficients close to 2 (31, 45). The dimeric model may be an oversimplification, since there are reports that other radioligands (e.g. [3H]nemonapride) are able to label more receptors than [3H]spiperone (19,21), suggesting that higher order species than dimers may exist. The present data are, however, consistent with homodimers.