European Journal of Pharmacology: Molecular Pharmacology
Molecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2A receptor☆
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Alkylation of sulfhydryl groups on Gα<inf>s/olf</inf> subunits by N-ethylmaleimide: Regulation by guanine nucleotides
2003, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Similar to other GPCRs, adenosine receptors have the characteristic secondary structure of seven α-helical membrane spanning domains connected by three extra- and intracellular loops, respectively. Sequence analysis of A2A adenosine receptors from various species has shown that this receptor subtype is particularly rich in cysteine residues in the extracellular loops and transmembrane domains [9,10]. Some of the cysteine residues in the extracellular loops may form disulfide bridges stabilizing receptor structural features [11,12].
Molecular modelling of the human A2b adenosine receptor and an analysis of the binding modes of its selective ligands
2002, Mendeleev CommunicationsSite-directed mutagenesis studies of human A(2A) adenosine receptorsInvolvement of glu<sup>13</sup> and his<sup>278</sup> in ligand binding and sodium modulation
2000, Biochemical PharmacologyCitation Excerpt :In the present study, the interactions between the human A2A adenosine receptor and its ligands were investigated by site-directed mutagenesis. In a previous molecular modeling study [17], it had been suggested that a glutamic acid in the first transmembrane domain (Glu13) and a histidine in the seventh transmembrane domain (His278) are somehow linked and that they are involved in agonist binding to the A2A adenosine receptor and its ligands. We followed up on this study by analyzing the binding behavior of the wild-type and the E13Q and H278Y receptors to agonists and antagonists under various conditions.
Adenosine A(2A) receptor interactions with receptors for other neurotransmitters and neuromodulators
1999, European Journal of PharmacologyIdentification of the adenine binding site of the human A<inf>1</inf> adenosine receptor
1999, Journal of Biological ChemistryCentral adenosine A(2A) receptors: An overview
1999, Brain Research Reviews
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The previous paper in this series appeared in Drug Design and Discovery 9, 49–67 (1992).