ReviewAnandamide, an endogenous cannabinomimetic eicosanoid: ‘Killing two birds with one stone’
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2019, European Journal of Medicinal ChemistryCitation Excerpt :Since cholinergic neurons do not express 5-HT6R [84], the higher release of ACh is derived from increased extracellular glutamate [85] and GABA [86–88] levels which in turn lead to the release ACh [89]. The cannabinoid G protein-coupled receptors (GPCRs) consists of two subtypes, CB1R and CB2R [90]. Agonism of hCB1R leads to the well-known psychoactive effects of (−)-trans-Δ9-tetrahydrocanabinol (Δ9-THC) [91].
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