Immediate-early genes induced by antigen receptor stimulation
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Cited by (49)
RNA-Seq and protein mass spectrometry in microdissected kidney tubules reveal signaling processes initiating lithium-induced nephrogenic diabetes insipidus
2019, Kidney InternationalCitation Excerpt :Prior phosphoproteomic studies revealed that within 9 hours of LiCl administration, before a measurable decrease in AQP2 protein abundance, both ERK1 and ERK2 underwent increases in active-site phosphorylation, indicative of increased kinase activity.8 Studies of growth factor signaling32 and signaling downstream from the T-cell receptor in T-lymphocytes25 have demonstrated a central role for ERK1/ ERK2 in initiation of the immediate early response, triggered in part by ERK-mediated phosphorylation of Ets family and AP1 family transcription factors. Thus, the 2 earliest responses in CD cells, viz. ERK activation and the immediate early transcriptional response, may be causally related.
Ikaros limits follicular B cell activation by regulating B cell receptor signaling pathways
2016, Biochemical and Biophysical Research CommunicationsCitation Excerpt :142 genes, including immediate early genes like Fos, Junb, Nr4a1, Nr4a2, Gadd45b, Nfkbai, Klf4, Gem, Id2 and Tnfaip3 [19–21], were already detected in unstimulated IkL/L cells but induced only after 3 h in WT cells (Fig. 2C). Other genes, including those encoding signaling inhibitors like Lax1, Cd22, Btla, Sla and Tbc1d10c [22–28], were decreased in unstimulated IkL/L cells, but only down-regulated after 3 h in WT cells (Fig. 2B, cluster c). BTLA down-regulation in naive IkL/L B cells was confirmed at the protein level (Fig. 2E).
Super-enhancers: Asset management in immune cell genomes
2015, Trends in ImmunologyA genome-wide methylation study of severe vitamin d deficiency in African American adolescents
2013, Journal of PediatricsCitation Excerpt :Because the expression is rapidly up-regulated in activated T cells, MAPRE2 is considered to be a member of the immediate-early T-cell regulatory gene family.28 The proteins encoded by the immediate-early gene can act as pleiotropic regulators of cellular activation, such as transcription factors and proteins involved in signal transduction cascades.30 MAPRE2 can also be found in rapidly proliferating tumor cells and its expression correlates with the cell cycle activity indicates that its protein (RP1) might be critically involved in processes controlling cell proliferation.28,31
Towards a molecular understanding of the differential signals regulating αβ/γδ T lineage choice
2010, Seminars in ImmunologyCitation Excerpt :The greater ERK activation associated with adoption of the γδ fate appears to be functionally important as γδ commitment can be impaired in vitro using pharmacologic inhibitors of ERK signaling (S.-Y. Lee, Unpublished observation); however, the requirement for ERK in γδ lineage commitment and development has not been rigorously tested genetically. ERK/MAPK induces the expression of immediate early gene, zinc-finger transcription factors of the Egr family [77], which we and others have shown to be critical for normal thymocyte development [78–80]. The Egr family of transcription factors contains four members: Egr1, Egr2, Egr3, and Egr4.