Structure/function studies of lin-12/Notch proteins
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Cited by (106)
Methyllysine binding domains: Structural insight and small molecule probe development
2017, European Journal of Medicinal ChemistryCitation Excerpt :Finally, both UNC5114 and UNC5115 were able to competitively inhibit the PRC2 complex in the presence of H3K27me3. Ankyrin repeat motifs (also referred to as cdc10/SWI6 motifs or ANK) were first recognized in yeast cdc10/SWI6 cell cycle regulatory proteins and Drosophila LIN-12/Notch signaling proteins [155–157]. However, they were eventually named for the cytoskeletal protein ankyrin, which contains 24 copies of this repeat [158].
Notch inhibitors for cancer treatment
2013, Pharmacology and TherapeuticsCitation Excerpt :Notch was first identified as an oncogene in T-cell acute lymphoblastic leukemia (T-ALL) in which at (7;9) chromosomal translocation fuses the N-terminal region of the T-cell receptor beta (TCRβ) to the C-terminus of Notch1 (Ellisen et al., 1991). This leads to expression of a truncated Notch1 protein lacking the extracellular subunit and hence constitutively active (Greenwald, 1994). It was later discovered that over 50% of T-ALL have a variety of mutations that activate Notch1 (Weng et al., 2004).
The Notch signaling pathway in the cnidarian Hydra
2007, Developmental BiologyXMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner
2006, Mechanisms of Development