Novel indolocarbazole protein kinase c inhibitors with improved biochemical and physicochemical properties

https://doi.org/10.1016/0960-894X(94)00458-RGet rights and content

Abstract

Novel lactam and imide indolocarbazoles were synthesized and characterized with respect to inhibition of protein kinase C and other protein kinases. In both series potent and selective PKC inhibitors could be identified. Structure activity relationships are discussed.

Novel lactam and imide indolocarbazoles were synthesized and characterized with respect to inhibition of protein kinase C and other protein kinases.

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