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The ATP-dependent glutathione S-conjugate export pump

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Abstract

The ATP-dependent glutathione S-conjugate export pump (GS-X pump) plays a physiologically important role as a member of the ‘phase III’ system in xenobiotic metabolism as well as in the release of biologically active endogenous substances from cells. In addition, this export pump is potentially involved in the modulation of the antiproliferative action of certain antitumor agents.

References (34)

  • T. Ishikawa

    Trends Biochem. Sci.

    (1990)
  • K. Kobayashi et al.

    J. Biol. Chem.

    (1990)
  • T.P.M. Akerboom et al.

    J. Biol. Chem.

    (1991)
  • T. Ishikawa

    J. Biol. Chem.

    (1989)
  • J.D. Hayes et al.

    Pharmacol. Ther.

    (1991)
  • T. Ishikawa et al.

    FEBS Lett.

    (1989)
  • M.K. Bach et al.

    Arch. Biochem. Biophys.

    (1984)
  • B.K. Lam et al.

    J. Biol. Chem.

    (1989)
  • T. Schaub et al.

    FEBS Lett.

    (1991)
  • T. Ishikawa

    J. Biol. Chem.

    (1990)
  • K.V. Honn et al.

    Biochem. Biophys. Res. Commun.

    (1985)
  • K. Ohno et al.

    J. Biol. Chem.

    (1988)
  • J.A. Endicott et al.

    Annu. Rev. Biochem.

    (1989)
  • T. Kitamura
  • J. Fernandez-Chea

    J. Biol. Chem.

    (1992)
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