Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers
References (14)
- et al.
The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells
Biochem Biophys Res Commun
(1999) - et al.
Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicalseffect of vitamin C
Free Radic Biol Med
(1999) - et al.
Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidationa human in vivo study
J Am Coll Cardiol
(2001) - et al.
Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans
J Am Coll Cardiol
(2001) - et al.
Effects of nonintermittent treatment of rabbits with pentaerythritol tetranitrate on vascular reactivity and superoxide production
Eur J Pharmacol
(1998) - et al.
Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate
Biochem Biophys Res Commun
(2002) - et al.
The nitric oxide donor pentaerythritol tetranitrate can preserve endothelial function in established atherosclerosis
Br J Pharmacol
(2001)
Cited by (46)
Coronary Heart Disease and Myocardial Ischemia
2022, Comprehensive PharmacologyOrganic nitrates: Update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction
2014, Vascular PharmacologyCitation Excerpt :There is now evidence that tolerance might not be a class effect, and that the nitrate PETN might be a remarkable exception in this regard. In contrast with other long-acting nitrates, studies with PETN in healthy volunteers showed preserved vasodilatory potency, as well as absence of oxidative stress and endothelial dysfunction [38,55] during continuous treatment with this nitrate. In animals, PETN was reported to prevent endothelial dysfunction as well as atherogenesis [56], which might be mediated by its capacity to induce the antioxidant defense protein heme oxygenase-1 (HO-1).
Modulating the NO generating system from a medicinal chemistry perspective: Current trends and therapeutic options in cardiovascular disease
2010, Pharmacology and TherapeuticsOrganic nitrates and nitrate tolerance-state of the art and future developments
2010, Advances in PharmacologyCitation Excerpt :Nitrates were developed and approved at a time when large-scale, long-term, randomized trials were not required, and the absence of patent rights on these medications does not encourage any industry to finance a large-scale clinical trial. Evidence to date emphasizes the importance of such a trial, as smaller trials have pointed out potential deleterious effects of this therapy: studies in healthy volunteers have demonstrated that nitroglycerin and other nitrates, with the possible exception of PETN, cause endothelial and autonomic dysfunction, and paradoxical coronary vasoconstriction (Caramori et al., 1998; Gori et al., 2002, 2003a; Schulz et al., 2002). In line with these findings, two clinical trials and a metaanalysis showed a trend toward an increase in mortality under nitrate therapy (Table I).
This research was funded by a Grant-in-Aid B3160 from the Heart and Stroke Foundation of Ontario, Toronto, Ontario, Canada. Drs. Gori and Al-Hesayen are supported by a Research Fellowship, and Dr. Parker is the recipient of a Career Investigator Award from the Heart and Stroke Foundation of Ontario, Toronto, Ontario, Canada.