Research paperNitric oxide-independent suppression of P450 2C11 expression by interleukin-1β and endotoxin in primary rat hepatocytes☆,☆☆
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2018, Biochemical PharmacologyCitation Excerpt :Hepatic drug metabolism studies have found that direct injections of IL-1β, IL-6, TNF-α, and IFN-γ act through downregulated CYP gene expression, which suppresses CYP amount and activity [10–12]. Sewer and Morgan [13,14] found that NO is not required for the suppression of CYP activity, mRNA, and protein by cytokines or lipopolysaccharide in hepatocytes. Therefore, post-translational NO modifications of hepatic CYP enzymes probably do not significantly contribute to drug-disease interactions in T helper 1 cell-dependent diseases.
Posttranslational regulation of CYP2J2 by nitric oxide
2018, Free Radical Biology and MedicineCitation Excerpt :Unlike those mentioned above, not all P450 proteins are sensitive to down-regulation by NO (eg. CYP2C11 and CYP3A4) [14,16,17]. Therefore, in the current study we tested the effect of NO on the expression and activity of CYP2J2.
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This work was presented, in part, at the XIth International Symposium on Microsomes and Drug Oxidations, Los Angeles, CA.
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This work was supported by a Shannon Award from the National Institutes of Health (GM/OD 53093) and a Howard Hughes Predoctoral Fellowship.