Suppressor and oncogenic roles of transforming growth factor-β and its signaling pathways in tumorigenesis
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2019, International Journal of Biological MacromoleculesRB1CC1 protein positively regulates transforming growth factor-β signaling through the modulation of Arkadia E3 ubiquitin ligase activity
2011, Journal of Biological ChemistryCitation Excerpt :The TGF-β-Smad pathway is also thought to have tumor suppressor functions during the early stages of tumorigenesis as TGF-β exhibits potent antiproliferative activity in a wide variety of cells. Additionally, mutations of signaling components downstream of TGF-β have been identified in tumor tissues (66). In this study we demonstrated that RB1CC1 is a positive regulator of TGF-β signaling under physiological conditions; knockdown of RB1CC1 attenuated expression of target genes as well as cytostasis induced by TGF-β.
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