Transcriptional Regulation of the Genes Encoding the Cytochrome P-450 Steroid Hydroxylases
References (121)
- et al.
Effect of ACTH on the stability of mRNAs encoding bovine adrenocortical P450scc, P45011**, P45017a, P450c21, and adrenodoxin.
Biochem. Biophys. Res. Commun.
(1989) - et al.
The CREB family of transcription activators.
Curr. Opin. Genet. Dev.
(1992) - et al.
The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extraden-ticle, another homeoprotein.
Cell
(1994) - et al.
The purification, cloning and expression of a novel LH-induced mitochondrial protein in MA-10 mouse Leydig tumor cells: Characterization of the steroidogenic acute regulatory protein (StAR).
J. Biol. Chem.
(1994) - et al.
Glucocorticoid-remediable aldosteronism.
Endocrinol. Metab. Clin. North Am.
(1994) - et al.
Role of DNA methylation in the regulation of transcription.
Curr. Opin. Genet. Deu.
(1994) - et al.
Actions of two different cAMP-responsive sequences and an enhancer of the human CYP11A1 (P450scc) gene in adrenal Y1 and placental JEG-3 cells.
J. Biol. Chem.
(1994) - et al.
An enhancer element and a functional cAMP-dependent protein kinase are required for expression of adrenocortical 21-hydroxylase.
J. Biol. Chem.
(1988) - et al.
Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
J. Biol. Chem.
(1993) - et al.
Evidence that an adrenal-specific nuclear protein regulates the cAMP responsiveness of the human CYP21B (P450C21) gene.
J. Biol. Chem.
(1991)
Purification and characterization of a transcription factor which appears to regulate cAMP responsiveness of the human CYP21B gene.
J. Biol. Chem.
(1992)
A cAMP-regulatory sequence (crsl) of cypl7 is a cellular target for the homeodomain protein pbx.
J. Biol. Chem.
(1994)
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML.
Cell
(1991)
A new homeobox gene contributes to the DNA binding domain of the t(1;19) translocation protein in pre-B. ALL.
Cell
(1990)
Congenital adrenal hypoplasia and isolated gonadotropin deficiency.
Trends Endocrinol. Metab.
(1991)
Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner membranes in adrenocortical cells.
J. Biol. Chem.
(1990)
Structure, function, and tissue-specific gene expression of 3 beta-hydroxysteroid dehydro-genase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues.
J. Steroid Biochem. Mol. Biol.
(1992)
Regulation of CYP11A gene expression in bovine ovarian granulosa cells in primary culture by cAMP and phorbol esters is conferred by a common cisacting element.
Mol. Cell. Endocrinol.
(1993)
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.
Cell
(1994)
Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain.
Brain Res.
(1993)
Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.
Neuron
(1988)
An element regulating adrenal-specific steroid 21-hydroxylase expression is located within the Sip gene.
J. Biol. Chem.
(1992)
Characterization of two genes encoding human steroid 11**-hydroxylase (P45011**).
J. Biol. Chem.
(1989)
A common trans-acting factor, Ad4BP, to the promoters of steroidogenic P450s.
J. Biol. Chem.
(1992)
Transcriptional regulation of the adrenal steroidogenic enzymes.
Trends Endocrinol. Metab.
(1993)
Sterol carrier protein 2: A role in steroid hormone synthesis?
J. Steroid Biochem. Mol. Biol.
(1993)
Acute ACTH regulation of adrenal corticosteroid biosynthesis. Rapid accumulation of a phosphoprotein.
J. Biol. Chem.
(1986)
A cAMP-responsive element regulates expression of the mouse steroid lip-hydroxylase gene.
J. Biol. Chem.
(1989)
Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme.
J. Biol. Chem.
(1990)
Neurosteroids: Biosynthesis and function.
Trends Endocrinol. Metab.
(1994)
Nuclear receptor steroidogenic factor 1 regulates MIS gene expression: A link to the sex determination cascade.
Cell
(1994)
Estrogen biosynthesis in the ovaries and testes.
Adv. Sex Horm. Res.
(1977)
A novel 3′,5′-cyclic adenosine monaphosphate-responsive sequence in the bovine CYP17 gene is a target of negative regulation by protein kinase C.
Mol. Endocrinol.
(1992)
Mutually exclusive interactions of two nuclear receptors determine activity of a cyclic adenosine 3′,5′-monophosphate-responsive sequence in the bovine CYP17 gene.
Mol. Endocrinol.
(1995)
The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone alpha-subunit gene in pituitary go-nadotropes.
Mol. Endocrinol.
(1994)
The role of calcium in angiotensin II-mediated aldosterone secretion.
Endocr. Rev.
(1989)
Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid ll**-hydroxylase.
Mol. Endocrinol.
(1990)
Tissue-specific, cAMP-induced, and phorbol ester repressed expression from the human P450cl7 promoter in mouse cells.
Mol. Endocrinol.
(1990)
Purification and biochemical characterization of the promoter-specific transcription factor, Spl.
Science
(1986)
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
J. Clin. Endocrinol. Metab.
(1994)
Phosphorylated CREB binds specifically to the nuclear protein CBP.
Nature
(1993)
Steroidogenic factor 1 binding and transcriptional activity of the cholesterol side chain cleavage promoter in rat granulosa cells.
Endocrinology
(1994)
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.
Mol. Cell. Biol.
(1992)
ErbA: Tumor suppressor turned oncogene?
FASEB J.
(1993)
Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands.
Mol. Cell. Biol.
(1994)
Different isozymes of mouse 11**-hydroxylase produce mineralocorticoids and glucocorticoids.
Mol. Endocrinol.
(1991)
The steroid and thyroid hormone receptor superfamily.
Science
(1988)
Cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3′,5′-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells.
Mol. Endocrinol.
(1993)
Identification of a cyclic adenosine 3′,5′-monophosphate-response element in the rat promoter that is required for transcriptional activation in rat granulosa cells and R2C Leydig cells.
Mol. Endocrinol.
(1994)
The polypeptide diazepam-binding inhibitor and a higher affinity mitochondrial peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumor cell line.
J. Biol. Chem.
(1994)
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