Cell
Volume 108, Issue 5, 8 March 2002, Pages 587-590
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Opioid Tolerance–In Search of the Holy Grail

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Abstract

Tolerance, one of several behavioral adaptations to prolonged opioid treatment, has long been explained by desensitization of opioid receptor signaling and loss of surface receptors. However, recent evidence presents an alternative hypothesis, suggesting that receptor internalization could in fact reduce tolerance in vivo.

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