Trends in Pharmacological Sciences
ReviewHow should P2x purinoceptors be classified pharmacologically?
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Cited by (166)
ATP as a cotransmitter in the autonomic nervous system
2015, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The neurotransmitter actions of NA are terminated by uptake back into sympathetic nerves via a well-characterised transporter. In contrast, ATP is rapidly broken down in the synapse (Evans and Kennedy, 1994; Kennedy and Leff, 1995) and the majority of ATP released is detected as adenosine (Todorov et al., 1996). Four extracellular, membrane-bound ecto-nucleoside triphosphate diphosphohydrolases (NTPDase1, 2, 3 and 8), two ecto-nucleotide pyrophosphatases/phosphodiesterases (NPP1 and 3) and an ecto-5′-nucleotidase have been identified, which dephosphorylate ATP to ADP, AMP and adenosine (Robson et al., 2006).
Alpha, beta methylene ATP
2007, xPharm: The Comprehensive Pharmacology Reference2-MeSATP
2007, xPharm: The Comprehensive Pharmacology ReferenceHuman airway ecto-adenylate kinase: A mechanism to propagate ATP signaling on airway surfaces
2003, Journal of Biological ChemistryCitation Excerpt :P2XRs may desensitize rapidly, i.e. within ∼30 s (16, 20), suggesting that a prolonged ATP level may not be important for signaling. On the other hand, P2YRs are activated by lower ATP concentrations (EC50 = 0.1–1 μm; for a review, see Ref. 21) and desensitize less rapidly. For instance, Cl− currents (61) and CBF (19) induced by 100 μm ATP on airway epithelial surfaces remained above 60% of maximal response for at least 15 min.
Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth: Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor
2002, Journal of Biological ChemistryCitation Excerpt :A similar shift in the concentration-dependent curve was also observed in the presence of ATP-regenerating system (Fig. 3 B). Because the concentration range of ATP found to stimulate DNA synthesis could activate both P2Y and P2X receptors (11, 34, 35), we evaluated the effects of selective P2Y and P2X receptor agonists on DNA synthesis. We found that the P2Y receptor agonists UTP, ADPβS, and the P2Y/P2X agonist MeSATP stimulated increases in thymidine incorporation which were nearly equivalent to those observed with ATP at doses causing a maximal effect (Fig. 3C).