Corticosteroids and tuberculosis
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2020, Journal of Clinical Tuberculosis and Other Mycobacterial DiseasesCitation Excerpt :Clinical suspicion and radiological findings are very important for an early diagnosis and a correct treatment. It is important to evaluate HIV status among other conditions of immunosuppression including age, uncontrolled diabetes, chemotherapy, organ transplant, and corticosteroid therapy [2,10–12]. To confirm the diagnosis a microbiological isolation is necessary.
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2007, Revue de Medecine InterneTuberculosis in patients with systemic rheumatic or pulmonary diseases treated with glucocorticosteroids and the preventive role of isoniazid: a review of the available evidence
2007, International Journal of Antimicrobial AgentsCitation Excerpt :One of these infections is tuberculosis (TB), however there has been no review in the medical literature evaluating the risk of development of TB in patients receiving glucocorticosteroids for the treatment of various systemic rheumatic and chronic pulmonary diseases compared with the risk of TB in the general population [5,19]. Furthermore, there is much controversy among clinicians regarding the role of isoniazid prophylaxis (INHP) in preventing reactivation of old or development of new TB infection in these immunosuppressed patients [24–28]. There are data suggesting that INHP is effective in purified protein derivative (PPD) tuberculin skin test-positive patients with haematological malignancies and chronic renal haemodialysis as well as renal transplant recipients [29,30], although the clinical utility of such a strategy has not been fully clarified in clinical practice.
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