Microtubules and actin filaments: dynamic targets for cancer chemotherapy
References (97)
- et al.
Opposite end assembly and disassembly of microtubules at steady state in vitro
Cell
(1978) - et al.
Taxol stabilizes microtubules in mouse fibroblasts cells
Proc Natl Acad Sci USA
(1980) - et al.
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
Proc Natl Acad Sci USA
(1993) - et al.
Unusually potent suppression of microtubule dynamics by crytophycin 1: a mechanism for its antiproliferative action
Biochemistry
(1997) - et al.
Mechanism of inhibition of cell proliferation by Vinca alkaloids
Cancer Res
(1991) - et al.
Raf-1/bcl2 phosphorylation: a step from microtubule damage to cell death
Cancer Res
(1997) - et al.
Differential taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells
J Cell Biol
(1996) - et al.
Cellular targets of the anti-breast cancer agent Z-1, 1-dichloro-2,3-diphenylcyclopropane; type II estrogen binding sites and tubulin
Anticancer Res
(1997) - et al.
G-actin as a risk factor and modulatable endpoint for cancer prevention trials
J Cell Biochem
(1996) - et al.
Widespread loss of gelsolin in breast cancers of humans, mice, and rats
Cancer Res
(1996)
Dynamic instability of microtubule growth
Nature
(1984)
Microtuble treadmills-possible molecular machinery
Nature
(1981)
Microtubule treadmilling in vivo
Science
(1997)
Microtubule dynamics: treadmilling comes around again
Curr Biol
(1997)
Exchange of actin subunits in the leading edge of living fibroblasts: possible of treadmilling
J Cell Biol
(1985)
Actin microfilament dynamics in locomoting cells
Nature
(1991)
Kinetochores capture astral microtubules during chromosomes attachment to the mitotic spindle: direct visualization in live newt cells
J Cell Biol
(1990)
Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle
J Cell Biol
(1990)
Microtubule dynamics: taking aim at a moving target
Chem Biol
(1995)
Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton
J Cell Biol
(1997)
Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue
Cancer Res
(1991)
(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest
Chem Biol
(1996)
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
Biochemistry
(1996)
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R))
J Biol Chem
(1997)
Vinblastine suppresses dynamics of individual microtubules in living cells
Mol Biol Cell
(1995)
Differential effects of vinblastine on polymerization and dynamics at opposite microtubule ends
J Biol Chem
(1996)
Kinetic stabilization of microtubule dynamics at steady state in vitro by substoichiometric concentrations of tubulin-colchicine complex
Biochemistry
(1995)
Nanomolar concentrations on nocodazole alter microtubule dynamic instability in vivo and in vitro
Mol Biol Cell
(1997)
Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: A possible mechanistic basis for its antitumor action
Proc Natl Acad Sci USA
(1997)
Substoichiometric binding of taxol suppresses microtubule dynamics
Biochemistry
(1995)
Chromosomes initiate spindle assembly upon experimental dissolution of the nuclear envelope in grasshopper spermatocytes
J Cell Biol
(1995)
Mitotic block in HeLa cells by vinblastine: ultrastructural changes in kinetochore-microtubule attachment and in centrosomes
J Cell Sci
(1993)
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis
J Cell Sci
(1992)
Abnormal centrosome amplications in the absence of p53
Science
(1996)
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
Mol Biol Cell
(1996)
The low potency of taxol at microtubule minus ends: implications for its therapeutic mechanism
Cancer Res
(1998)
Mitotic forces control a cell-cycle checkpoint
Nature
(1995)
Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint
J Cell Biol
(1995)
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetchores
J Cell Biol
(1995)
Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
Science
(1996)
Identification of a human mitotic checkpoint gene: hsMAD2
Science
(1996)
Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast
Curr Biol
(1996)
GFP tagging of budding yeast chromosomes reveals that protein—protein interactions can mediate sister chromatid cohesion
Curr Biol
(1996)
The spindle assembly checkpoint
Curr Biol
(1996)
Kinetochore fiber maturation in PtK1 cells and its implications for the mechanisms of chromosome congression and anaphase onset
J Cell Biol
(1997)
Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle
Cancer Res
(1992)
Mitotic block induced in HeLa cells by low concentration of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
Cancer Res
(1996)
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